N-[2-(pyridine-4-carbonylamino)ethyl]pyridine-4-carboxamide

Base Information

• Chemical Name: N-[2-(pyridine-4-carbonylamino)ethyl]pyridine-4-carboxamide
• CAS No.: 6631-22-7
• Molecular Formula: C14H14 N4 O2
• Molecular Weight: 270.291
• NSC Number: 53073
• DSSTox Substance ID: DTXSID80984879
• Nikkaji Number: J1.984.651B
• Mol file: 6631-22-7.mol

Synonyms:6631-22-7;N-[2-(pyridine-4-carbonylamino)ethyl]pyridine-4-carboxamide;N,N'-Bisisonicotinoylethylenediamine;N,N'-Ethylenediisonicotinamide;NIOSH/NS0200000;Isonicotinamide, N,N'-ethylenedi-;N,N//'-Bisisonicotinoylethylenediamine;NS02000000;NSC53073;Cambridge id 5106634;CBDivE_002304;SCHEMBL9339173;DTXSID80984879;NSC-53073;STK095754;N,N'-1,2-Ethanediyldiisonicotinamide;AKOS000623742;N,N'-ethane-1,2-diyldipyridine-4-carboxamide;N-[2-(isonicotinoylamino)ethyl]isonicotinamide;AB00073755-01;AH-034/32474019;N,N'-(Ethane-1,2-diyl)di(pyridine-4-carboxamide);N-{2-[(PYRIDIN-4-YL)FORMAMIDO]ETHYL}PYRIDINE-4-CARBOXAMIDE

Chemical Property of N-[2-(pyridine-4-carbonylamino)ethyl]pyridine-4-carboxamide

Chemical Property:

• Boiling Point: 647.6oC at 760 mmHg
• Flash Point: 345.5oC
• PSA: 83.98000
• Density: 1.242g/cm3
• LogP: 1.41820
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 270.11167570
• Heavy Atom Count: 20
• Complexity: 291

Purity/Quality:

N,N'-1,2-ETHANEDIYLBIS-4-PYRIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1C(=O)NCCNC(=O)C2=CC=NC=C2

Technology Process of N-[2-(pyridine-4-carbonylamino)ethyl]pyridine-4-carboxamide

There total 4 articles about N-[2-(pyridine-4-carbonylamino)ethyl]pyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

pyridine-4-carboxylic acid (55-22-1) + ethylenediamine (107-15-3,85404-18-8) → N,N′-bis(4-pyridinecarboxamide)-1,2-ethane (6631-22-7)

Guidance literature:

pyridine-4-carboxylic acid; ethylenediamine; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 48h;

DOI:10.1039/c2dt31313h

Reference yield:

isonicotinoyl chloride hydrochloride (39178-35-3) + ethylenediamine (107-15-3,85404-18-8) → N,N′-bis(4-pyridinecarboxamide)-1,2-ethane (6631-22-7)

Guidance literature:

With pyridine;

DOI:10.1021/jo01370a009

Reference yield:

4-pyridinecarboxylic acid, methyl ester (2459-09-8) + ethylenediamine (107-15-3,85404-18-8) → N,N′-bis(4-pyridinecarboxamide)-1,2-ethane (6631-22-7)

Guidance literature:

DOI:10.1021/jo01095a021

upstream raw materials:

4-pyridinecarboxylic acid, methyl ester

ethylenediamine

isonicotinoyl chloride hydrochloride

pyridine-4-carboxylic acid