Technology Process of Carbamic acid,
[(1S,2S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-1-phenylpent
yl]-, 1,1-dimethylethyl ester
There total 8 articles about Carbamic acid,
[(1S,2S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-1-phenylpent
yl]-, 1,1-dimethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl (1S,2S)-2-(tert-butyldimethylsilyloxy)-1-phenylpent-4-enylcarbamate;
With
diborane-dimethylsulfide complex;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
With
sodium hydroxide; dihydrogen peroxide;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1021/ol0528235
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 99 percent / Et3N / CH2Cl2 / 38 h / 20 °C
2.1: DIBALH / CH2Cl2; toluene / 3.5 h / -78 °C
3.1: 379 mg / poly(4-(carboxymethylaminosulfonyl)styrene) with 2 percent DVB / acetonitrile / 20 °C
4.1: 89 percent / 2,6-lutidine / CH2Cl2 / 0 °C
5.1: B2H6*Me2S / tetrahydrofuran / 4 h / 20 °C
5.2: 74.5 percent / aq. NaOH; aq. H2O2 / tetrahydrofuran / 20 °C
With
2,6-dimethylpyridine; diborane-dimethylsulfide complex; poly(4-(carboxymethylaminosulfonyl)styrene) with 2 percent DVB; diisobutylaluminium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ol0528235
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 78 percent / SOCl2 / Heating
2.1: 99 percent / Et3N / CH2Cl2 / 38 h / 20 °C
3.1: DIBALH / CH2Cl2; toluene / 3.5 h / -78 °C
4.1: 379 mg / poly(4-(carboxymethylaminosulfonyl)styrene) with 2 percent DVB / acetonitrile / 20 °C
5.1: 89 percent / 2,6-lutidine / CH2Cl2 / 0 °C
6.1: B2H6*Me2S / tetrahydrofuran / 4 h / 20 °C
6.2: 74.5 percent / aq. NaOH; aq. H2O2 / tetrahydrofuran / 20 °C
With
2,6-dimethylpyridine; thionyl chloride; diborane-dimethylsulfide complex; poly(4-(carboxymethylaminosulfonyl)styrene) with 2 percent DVB; diisobutylaluminium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ol0528235