757195-53-2

Upstream product

• 143978-88-5 N-tert-butoxycarbonyl-L-phenylglycine methyl ester 
• 163061-19-6 (2S)-2-tert-butoxycarbonylamino-2-phenylacetaldehyde 
• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 
• 2935-35-5 (S)-2-phenylglycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 160237-87-6 (1S,2S)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-1-phenyl-4-pentene 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 757195-59-8 (2S,3S)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-phenylpiperidine-1-carboxylate 
• 159249-47-5 tert-butyl (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylate 
• 757195-54-3 tert-butyl (1S,2S)-2-(tert-butyldimethylsilyloxy)-5-hydroxy-1-phenylpentylcarbamate 

Relevant academic research and scientific papers

Allylation of aldehydes and imines: Promoted by reuseable polymer-supported sulfonamide of N-glycine

A allylation of aldehydes and imines (generated in situ from aldehydes and amines) with allyltributyltin promoted by recoverable and reusable the polymer-supported sulfonamide of N-glycine has been developed. Good to high yields were obtained in various cases. Most of the SnBu3 residue can be recovered as Bu3SnCl. Highly stereoselective synthesis of N-Boc-(2S,3S)-3-hydroxy-2-phenylpiperidine 7 was achieved by using the P4a-mediated allylation of Boc-L-phenylglycinal as a key step.

Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721

An enantioselective total synthesis of NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721, is described. The key steps are diastereoselective addition of vinyllithium to a chiral benzaldehyde oxime ether and diastereoselective borane reduction of