Technology Process of 1,4-Dithia-7-azaspiro[4.4]nonane-7,8-dicarboxylic acid,
7-(phenylmethyl) ester, (S)-
There total 1 articles about 1,4-Dithia-7-azaspiro[4.4]nonane-7,8-dicarboxylic acid,
7-(phenylmethyl) ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate;
In
dichloromethane;
Ambient temperature;
DOI:10.1021/jm00401a014
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3.22 g / HBr/glacial acetic acid / 3 h / Ambient temperature
2: 5.81 g / SOCl2 / 3 h / 95 - 100 °C
3: 4.25 g / N-methylmorpholine, diphenyl phosphorazidate / dimethylformamide / 18 h / Ambient temperature
With
4-methyl-morpholine; thionyl chloride; diphenyl phosphoryl azide; hydrogen bromide; acetic acid;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00127a033
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 3.22 g / HBr/glacial acetic acid / 3 h / Ambient temperature
2: 5.81 g / SOCl2 / 3 h / 95 - 100 °C
3: 4.25 g / N-methylmorpholine, diphenyl phosphorazidate / dimethylformamide / 18 h / Ambient temperature
4: 1.29 g / HBr/glacial acetic acid / Ambient temperature
5: 1.0539 g / Bio-Rad AG 50W-X2 (100-mesh, hydrogen form) / H2O; pyridine; ethanol
With
4-methyl-morpholine; thionyl chloride; Bio-Rad AG 50W-X2 (100-mesh, hydrogen form); diphenyl phosphoryl azide; hydrogen bromide; acetic acid;
In
pyridine; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00127a033
