Technology Process of Spiraprilat
There total 13 articles about Spiraprilat which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: 6.8 g / SOCl2 / 20 h / Heating
2: 3.86 g / p-toluenesulfonic acid / acetic acid / 44 h / Heating
3: 6.3 g / 20percent HBr/glacial acetic acid / 2 h / Ambient temperature
4: 3.64 g / 2.5 N aq. NaOH / methanol / 18 h / Ambient temperature
5: 1.) N,N-disuccinimidyl carbonate, pyridine, 2.) NEt3 / 1.) CH3CN, RT, 44 h, 2.) CH3CN, H2O, RT
6: 6.22 g / 2.5 N aq. NaOH / methanol / 20 h / Ambient temperature
With
pyridine; sodium hydroxide; thionyl chloride; di(succinimido) carbonate; hydrogen bromide; toluene-4-sulfonic acid; acetic acid; triethylamine;
In
methanol; acetic acid;
DOI:10.1021/jm00127a033
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1->3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature
2: 4.6 g / NEt3 / dimethylformamide / Ambient temperature
3: 6.22 g / 2.5 N aq. NaOH / methanol / 20 h / Ambient temperature
With
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00127a033
