3-(1-Benzoylpiperidin-4-yl)propanoic acid

Base Information

• Chemical Name: 3-(1-Benzoylpiperidin-4-yl)propanoic acid
• CAS No.: 75999-93-8
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.31600
• DSSTox Substance ID: DTXSID70598161
• Wikidata: Q82493884
• Mol file: 75999-93-8.mol

Synonyms:3-(1-benzoylpiperidin-4-yl)propanoic acid;75999-93-8;SCHEMBL543404;DTXSID70598161;OCUKEGTXSFDMCN-UHFFFAOYSA-N;AKOS011498927;NCGC00426070-01;3-(1-benzoyl 4-piperidyl) propionic acid;3-(1-benzoylpiperidin-4-yl)propionic acid;CS-0331126;A1-07638;F6609-8250

Chemical Property of 3-(1-Benzoylpiperidin-4-yl)propanoic acid

Chemical Property:

• PSA: 57.61000
• LogP: 2.34150
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 261.13649347
• Heavy Atom Count: 19
• Complexity: 315

Purity/Quality:

99% ^*data from raw suppliers

3-(1-Benzoylpiperidin-4-yl)propanoic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1CCC(=O)O)C(=O)C2=CC=CC=C2

Technology Process of 3-(1-Benzoylpiperidin-4-yl)propanoic acid

There total 6 articles about 3-(1-Benzoylpiperidin-4-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-piperidinyl)propionic acid hydrochloride (51052-79-0) + benzoyl chloride (98-88-4) → 3-(1-benzoyl 4-piperidyl)-propionic acid (75999-93-8)

Guidance literature:

With sodium acetate; In acetic acid;

Reference yield:

3-(4-piperidyl)propionic acid (1822-32-8) + benzoyl chloride (98-88-4) → 3-(1-benzoyl 4-piperidyl)-propionic acid (75999-93-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01252a068

Reference yield:

3-(1-nitroso-[4]piperidyl)-propionic acid → 3-(1-benzoyl 4-piperidyl)-propionic acid (75999-93-8)

Guidance literature:

With hydrogenchloride; copper(l) chloride; Erhitzen des Reaktionsprodukts mit wss. NaOH und Behandeln der Reaktionsloesung mit Benzoylchlorid;

DOI:10.1021/ja01237a507

upstream raw materials:

3-(4-piperidyl)propionic acid

benzoyl chloride

ethyl 3-(4-piperidinyl)propanoate hydrochloride

3-(pyridin-4-yl)acrylic acid

Downstream raw materials:

3-methoxycarbonyl-7-[3-(1-benzoylpiperidin-4-yl)-1-oxopropyl]-2,3,4,5-tetrahydro-1H-3-benzazepine

3-(1-benzoyl 4-piperidyl)-1-(4-fluorophenyl)-1-propanone