(3R,4S)-1-[4-(Aminomethyl)phenyl]-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-methoxyphenyl)-2-azetidinone

Base Information

Chemical Name:(3R,4S)-1-[4-(Aminomethyl)phenyl]-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-methoxyphenyl)-2-azetidinone
CAS No.:768394-93-0
Molecular Formula:C26H27FN2O3
Molecular Weight:434.51
Hs Code.:
European Community (EC) Number:616-401-4
DSSTox Substance ID:DTXSID001108100

Synonyms:SCHEMBL4000185;SCHEMBL5971943;DTXSID001108100;(3R,4S)-1-[4-(Aminomethyl)phenyl]-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-methoxyphenyl)-2-azetidinone;768394-93-0

Suppliers and Price of (3R,4S)-1-[4-(Aminomethyl)phenyl]-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-methoxyphenyl)-2-azetidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of (3R,4S)-1-[4-(Aminomethyl)phenyl]-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-methoxyphenyl)-2-azetidinone

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:434.20057089
Heavy Atom Count:32
Complexity:596

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2C(C(=O)N2C3=CC=C(C=C3)CN)CCC(C4=CC=C(C=C4)F)O
Isomeric SMILES:COC1=CC=C(C=C1)[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)CN)CC[C@@H](C4=CC=C(C=C4)F)O

Technology Process of (3R,4S)-1-[4-(Aminomethyl)phenyl]-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-methoxyphenyl)-2-azetidinone

There total 2 articles about (3R,4S)-1-[4-(Aminomethyl)phenyl]-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-methoxyphenyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3(R)-[3(S)-(tert-butyl-dimethyl-silyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-{[(4-methoxy-benzylidene)-amino]-methyl}-phenyl)-4(S)-(4-methoxy-phenyl)-azetidin-2-one

: 768394-93-0
1-(4-aminomethyl-phenyl)-3(R)-[3(S)-hydroxy-3-(4-fluorophenyl)-propyl]-4(S)-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:: With sulfuric acid; water; In 1,4-dioxane; at 20 ℃; for 0.666667h;

Reference yield:

: 768394-93-0
1-(4-aminomethyl-phenyl)-3(R)-[3(S)-hydroxy-3-(4-fluorophenyl)-propyl]-4(S)-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:

Reference yield: 32.0%

: 768394-93-0
1-(4-aminomethyl-phenyl)-3(R)-[3(S)-hydroxy-3-(4-fluorophenyl)-propyl]-4(S)-(4-methoxy-phenyl)-azetidin-2-one

: 768394-95-2
11-[(4R,5R)-4,5,6-trihydroxy-3-(R)-hydroxy-2-(S)-hydroxy-hexylcarbamoyl]-undecanoic acid

: 768394-99-6
Canosimibe

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃;