Canosimibe

Base Information

Chemical Name:Canosimibe
CAS No.:768394-99-6
Molecular Formula:C₄₄H₆₀FN₃O₁₀
Molecular Weight:809.973
Hs Code.:
UNII:2GG0K1I5CI
Wikidata:Q27254713
NCI Thesaurus Code:C91027

Synonyms:Canosimibe;Canosimibe [INN];Canosimibum;Canosimiba;UNII-2GG0K1I5CI;2GG0K1I5CI;768394-99-6;N-(1-deoxy-L-glucitol-1-C-yl)-N'-((4-{(2S,3R))-3-((3S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl}phenyl)methyl)dodecanediamide;N-[[4-[(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]phenyl]methyl]-N'-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]dodecanediamide;N-(1-DEOXY-L-GLUCITOL-1-C-YL)-N'-((4-((2S,3R))-3-((3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-2-(4-METHOXYPHENYL)-4-OXOAZETIDIN-1-YL)PHENYL)METHYL)DODECANEDIAMIDE;SCHEMBL12359199;AVE-5530;HY-19497;CS-0015597;Q27254713

Suppliers and Price of Canosimibe

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Canosimibe

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:26
Exact Mass:809.42627328
Heavy Atom Count:58
Complexity:1190

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2C(C(=O)N2C3=CC=C(C=C3)CNC(=O)CCCCCCCCCCC(=O)NCC(C(C(C(CO)O)O)O)O)CCC(C4=CC=C(C=C4)F)O
Isomeric SMILES:COC1=CC=C(C=C1)[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)CNC(=O)CCCCCCCCCCC(=O)NC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)CC[C@@H](C4=CC=C(C=C4)F)O
Recent EU Clinical Trials:A multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety and tolerability of AVE5530 when added to ongoing stable statin therapy at high doses in patients with severe primary hypercholesterolemia

Technology Process of Canosimibe

There total 3 articles about Canosimibe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 768394-93-0
1-(4-aminomethyl-phenyl)-3(R)-[3(S)-hydroxy-3-(4-fluorophenyl)-propyl]-4(S)-(4-methoxy-phenyl)-azetidin-2-one

: 768394-95-2
11-[(4R,5R)-4,5,6-trihydroxy-3-(R)-hydroxy-2-(S)-hydroxy-hexylcarbamoyl]-undecanoic acid

: 768394-99-6
Canosimibe

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

: 768394-97-4
acetic acid (2R,3R,4R,5S)-2,3,4,5-tetraacetoxy-6-(11-{4-[(2S,3R)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-methoxyphenyl)-4-oxo-azetidin-1-yl]-benzylcarbamoyl}-undecanoylamino)hexyl ester

: 768394-99-6
Canosimibe

Guidance literature:: With guanidine nitrate; In ethanol; dichloromethane;

Reference yield:

: 11-{4-[(2S,3R)-3-[(S)-3-(4-fuorophenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylcarbamoyl}undecanoic acid

: 488-43-7
1-Amino-1-deoxy-D-glucitol

: 768394-99-6
Canosimibe

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide);