1-(2-Bromo-1,1,1-trifluoropropan-2-yl)-4-methoxybenzene

Base Information

Chemical Name:1-(2-Bromo-1,1,1-trifluoropropan-2-yl)-4-methoxybenzene
CAS No.:76954-04-6
Molecular Formula:C10H10BrF3O
Molecular Weight:283.088
Hs Code.:
DSSTox Substance ID:DTXSID90541452
Nikkaji Number:J574.774K

Synonyms:1-(2-Bromo-1,1,1-trifluoropropan-2-yl)-4-methoxybenzene;76954-04-6;DTXSID90541452;LKGMKELBRSFBNB-UHFFFAOYSA-N

Suppliers and Price of 1-(2-Bromo-1,1,1-trifluoropropan-2-yl)-4-methoxybenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-(2-Bromo-1,1,1-trifluoropropan-2-yl)-4-methoxybenzene

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:281.98671
Heavy Atom Count:15
Complexity:211

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)OC)(C(F)(F)F)Br

Technology Process of 1-(2-Bromo-1,1,1-trifluoropropan-2-yl)-4-methoxybenzene

There total 4 articles about 1-(2-Bromo-1,1,1-trifluoropropan-2-yl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 76953-96-3
1-(4-methoxyphenyl)-1-(trifluoromethyl)ethanol

: 76954-04-6
1-(4-methoxyphenyl)-1-(trifluoromethyl)ethyl bromide

Guidance literature:: With phosphorus tribromide; RT, 30 min, 40 deg C, 2 h;
DOI:10.1021/ja00365a038

Reference yield:

: 711-38-6
4'-methoxy-2,2,2-trifluoroacetophenone

: 76954-04-6
1-(4-methoxyphenyl)-1-(trifluoromethyl)ethyl bromide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / diethyl ether / 0 deg C to room temp. then room temp., 1 h

2: 50 percent / PBr₃ / 25 h / 40 °C

With phosphorus tribromide; In diethyl ether;
DOI:10.1021/jo00074a036