2(5H)-Furanone, 4-(3,4-dimethoxyphenyl)-

Base Information

• Chemical Name: 2(5H)-Furanone, 4-(3,4-dimethoxyphenyl)-
• CAS No.: 7706-87-8
• Molecular Formula: C12H12O4
• Molecular Weight: 220.225
• Mol file: 7706-87-8.mol

Synonyms:

Chemical Property of 2(5H)-Furanone, 4-(3,4-dimethoxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(5H)-Furanone, 4-(3,4-dimethoxyphenyl)-

There total 5 articles about 2(5H)-Furanone, 4-(3,4-dimethoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

(E)-3-(3,4-Dimethoxy-phenyl)-but-2-enoic acid methyl ester (144465-19-0) → 4-(3,4-dimethoxy-phenyl)-5H-furan-2-one (7706-87-8)

Guidance literature:

With selenium(IV) oxide; perchloric acid; In acetic acid; at 100 ℃; for 8h;

DOI:10.1055/s-1992-26237

Reference yield:

3-(3,4-dimethoxy-phenyl)-crotonic acid ethyl ester (7706-60-7) → 4-(3,4-dimethoxy-phenyl)-5H-furan-2-one (7706-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / 24 h / Heating

2: 59 percent / SeO₂, HClO₄ / acetic acid / 8 h / 100 °C

With sodium hydroxide; selenium(IV) oxide; perchloric acid; In acetic acid;

DOI:10.1055/s-1992-26237

Reference yield:

α-acetoxy-3,4-dimethoxyacetophenone (39561-76-7) → 4-(3,4-dimethoxy-phenyl)-5H-furan-2-one (7706-87-8)

Guidance literature:

With ethyl bromoacetate; zinc; benzene; Erhitzen des nach der Hydrolyse (wss. Salzsaeure) erhaltenen Reaktionsprodukts mit Bromwasserstoff in Essigsaeure auf 120grad;

upstream raw materials:

α-acetoxy-3,4-dimethoxyacetophenone

(E)-3-(3,4-Dimethoxy-phenyl)-but-2-enoic acid methyl ester

3-(3,4-dimethoxy-phenyl)-crotonic acid ethyl ester

2-diazo-1-(3,4-dimethoxyphenyl)ethan-1-one

Refernces