2-Chloro-1-[4-(2-ethoxyphenyl)piperazin-1-yl]propan-1-one

Base Information

Chemical Name:2-Chloro-1-[4-(2-ethoxyphenyl)piperazin-1-yl]propan-1-one
CAS No.:77368-18-4
Molecular Formula:C₁₅H₂₁ClN₂O₂
Molecular Weight:296.797
Hs Code.:
DSSTox Substance ID:DTXSID50655903

Synonyms:77368-18-4;2-Chloro-1-[4-(2-ethoxyphenyl)piperazin-1-yl]propan-1-one;DTXSID50655903

Suppliers and Price of 2-Chloro-1-[4-(2-ethoxyphenyl)piperazin-1-yl]propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Chloro-1-[4-(2-ethoxyphenyl)piperazin-1-yl]propan-1-one

Chemical Property:

PSA：32.78000
LogP:2.36410
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:296.1291556
Heavy Atom Count:20
Complexity:319

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC=CC=C1N2CCN(CC2)C(=O)C(C)Cl

Technology Process of 2-Chloro-1-[4-(2-ethoxyphenyl)piperazin-1-yl]propan-1-one

There total 1 articles about 2-Chloro-1-[4-(2-ethoxyphenyl)piperazin-1-yl]propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 7623-09-8
2-chloropropionyl chloride

: 83081-75-8
1-(2-ethoxyphenyl)piperazine monohydrochloride

: 77368-18-4
1-(2-chloropropionyl)-4-(2-ethoxyphenyl)piperazine

Guidance literature:: With triethylamine; In chloroform; Ambient temperature;
DOI:10.1248/cpb.32.3981

Reference yield:

: 77368-18-4
1-(2-chloropropionyl)-4-(2-ethoxyphenyl)piperazine

: 83081-72-5
2-{2-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-ethyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Et₃N / ethanol / Heating

2: LiAlH₄ / 1.) ether, reflux; 2.) acetone

With lithium aluminium tetrahydride; triethylamine; In ethanol;
DOI:10.1248/cpb.32.3981

Reference yield:

: 77368-18-4
1-(2-chloropropionyl)-4-(2-ethoxyphenyl)piperazine

: 83081-71-4
2-{2-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-ethyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Et₃N / ethanol / Heating

2: 65 percent / LiAlH₄ / diethyl ether / Heating

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; ethanol;
DOI:10.1248/cpb.32.3981