5-IODO-6-METHYLPYRIMIDIN-4-OL

Base Information

• Chemical Name: 5-IODO-6-METHYLPYRIMIDIN-4-OL
• CAS No.: 7752-74-1
• Molecular Formula: C5H5IN2O
• Molecular Weight: 236.012
• Hs Code.: 2933599590
• Mol file: 7752-74-1.mol

Synonyms:5-Iodo-6-methylpyrimidin-4-ol;4(1H)-Pyrimidinone, 5-iodo-6-methyl- (9CI);5-Iodo-6-methyl-3H-pyrimidin-4-one;4-Pyrimidinol, 5-iodo-6-methyl- (7CI,8CI);

Chemical Property of 5-IODO-6-METHYLPYRIMIDIN-4-OL

Chemical Property:

• Boiling Point: 245.478 °C at 760 mmHg
• Flash Point: 102.262 °C
• PSA: 46.01000
• Density: 2.191 g/cm³
• LogP: 1.09520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Iodo-6-methylpyrimidin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-IODO-6-METHYLPYRIMIDIN-4-OL

There total 6 articles about 5-IODO-6-METHYLPYRIMIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-methyl-3H-pyrimidin-4-one (3524-87-6,156647-95-9) → 5-iodo-6-methyl-3H-pyrimidin-4-one (7752-74-1)

Guidance literature:

With Iodine monochloride; acetic acid; at 60 ℃;

DOI:10.1016/j.bmcl.2011.01.119

Reference yield: 49.0%

4-hydroxy-6-methylpyrimidine (3524-87-6,156647-96-0) → 4-hydroxy-5-iodo-6-methylpyrimidine (7752-74-1)

Guidance literature:

With iodine; sodium hydroxide; In water; for 3h; Reflux;

DOI:10.1016/j.bmc.2013.03.053

Reference yield:

4-hydroxy-6-methylpyrimidine (3524-87-6,156647-96-0) → 5-iodo-6-methyl-3H-pyrimidin-4-one (7752-74-1)

Guidance literature:

With N-iodo-succinimide; In acetic acid; at 20 ℃; for 30.25h;

upstream raw materials:

4-hydroxy-6-methylpyrimidine

6-methyl-2-thiouracil

6-methyl-3H-pyrimidin-4-one

Downstream raw materials:

4-chloro-5-iodo-6-methyl-pyrimidine

ethyl 5-(6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate

4-amino-6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidine

4-chloro-6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidine

Refernces

• 1、 -. "5-Alkynyl-pyridines". Paragraph 0177; 0178. . Retrieved 2013/03/26.
• 2、 -. "5-ALKYNYL-PYRIMIDINES". Page/Page column 8. . Retrieved 2012/02/06.