8-Nitrotryptanthrin

Base Information

• Chemical Name: 8-Nitrotryptanthrin
• CAS No.: 77603-42-0
• Molecular Formula: C15H7N3O4
• Molecular Weight: 293.238
• Mol file: 77603-42-0.mol

Synonyms:8-Nitroindolo[2,1-b]quinazoline-6,12-dione;8-Nitro-indolo[2,1-b]quinazoline-6,12-dione;

Chemical Property of 8-Nitrotryptanthrin

Chemical Property:

• Melting Point: >250 °C
• Boiling Point: 551.2±52.0 °C(Predicted)
• PKA: -7.55±0.20(Predicted)
• PSA: 97.78000
• Density: 1.67±0.1 g/cm3(Predicted)
• LogP: 2.36150
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99%+, ^*data from raw suppliers

8-Nitrotryptanthrin >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Nitrotryptanthrin

There total 7 articles about 8-Nitrotryptanthrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tryptanthrine (13220-57-0) → 8-nitroindolo[2,1-b]quinazoline-6,12-dione (77603-42-0)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; for 0.5h;

DOI:10.1016/S0960-894X(02)00431-6

Reference yield: 89.0%

isatoic anhydride (118-48-9) + 5-nitroisatin (611-09-6) → 8-nitroindolo[2,1-b]quinazoline-6,12-dione (77603-42-0)

Guidance literature:

With ZnO-NP; In ethanol; at 20 ℃; for 3h; Green chemistry;

DOI:10.1039/c7gc03479b

Reference yield:

isatoic anhydride (118-48-9) → 8-nitroindolo[2,1-b]quinazoline-6,12-dione (77603-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / toluene / Heating

2: 95 percent / conc. HNO₃; H₂SO₄ / 0.5 h / 0 °C

With sulfuric acid; nitric acid; triethylamine; In toluene;

DOI:10.1016/S0960-894X(02)00431-6

upstream raw materials:

isatoic anhydride

5-nitroisatin

tryptanthrine

indole-2,3-dione

Refernces

• 1、 -. "Tryptanthrin derivative and preparation thereof and application of tryptanthrin derivative in prevention and treatment of plant viruses and pathogenic bacteria". Paragraph 0018; 0032-0033. . Retrieved 2021/06/26.
• 2、 Nikoofar, Kobra,Peyrovebaghi, Seyedeh Shima. "1-Butyl-2-methylpipyridinium iodide ([BMPPY]I): novel ionic liquid for the synthesis of 6-hydroxy-6-(1H-indol-3-yl)indolo[2,1-b]quinazolin-12(6H)-ones under green solvent-free conditions". . p. 4287 - 4298. Retrieved 2019/04/30.