611-09-6Relevant articles and documents
Synthesis, antioxidant activity and SAR study of novel spiro-isatin-based Schiff bases
Sonmez, Fatih,Gunesli, Zuhal,Kurt, Belma Zengin,Gazioglu, Isil,Avci, Davut,Kucukislamoglu, Mustafa
, p. 829 - 844 (2019)
Abstract: A new series of 21 Schiff bases of spiro-isatin was synthesized, and their DPPH, CUPRAC and ABTS cation radical scavenging abilities were investigated for antioxidant activity. The results showed that all the synthesized compounds exhibited anti
Novel method for synthesis of isatins [3]
Mironov,Kleban,Mokrushin
, p. 368 - 369 (2001)
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Isoxazole formamido-4 (3H)-quinazolinone derivative as well as synthesis method and application thereof
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Paragraph 0020-0023, (2021/06/06)
The invention relates to a 6-(isoxazolyl-3-formamido)-4 (3H)-quinazolinone derivative as well as a synthesis method and application thereof, belongs to the technical field of medicines, and relates to a general formula (I) in which R1, R2 and R3 are different substituent groups. The invention discloses structures and synthesis methods of the compounds, inhibitory activity of acetylcholin esterase and inhibitory activity of protein tyrosine phosphatase, and the compounds can be further developed into drugs for treating Alzheimer's disease.
Microwave-Assisted Synthesis, Molecular Docking Studies and Biological Evaluation of Benzothiazole Containing Novel Indole Derivatives
Pandian, P.,Rajkamal, B.,Sultana, Shaheen
, p. 2755 - 2761 (2021/10/25)
The synthesis of novel indole derivatives 4a-o using a microwave assisted method via Schiff’s base and Mannich base reaction mechanism was described. Compounds 3a-c were synthesized via reaction of 2-amino benzothiazole with substituted isatin by Schiff base reaction mechanism. Also, indole derivatives 4a-o were synthesized via reaction of compounds 3a-c with substituted benzaldehydes by Mannich base reaction. The biological potentials of the newly synthesized indole derivatives were evaluated for their anthelmintic activity and in vitro anticancer activity by MTT assay. The anticancer activity results suggested that indole derivatives 4c-o have activity against MCF-7 and SKOV3 cells in comparison with doxorubicin as standard drug. Furthermore, the molecular docking studies of these novel derivatives of indole showed good agreement with the biological results when their binding pattern and affinity towards the active site of EGFR was also investigated.