Benzenepropanol, a-[(trimethylsilyl)ethynyl]-, methanesulfonate

Base Information

• Chemical Name: Benzenepropanol, a-[(trimethylsilyl)ethynyl]-, methanesulfonate
• CAS No.: 777060-75-0
• Molecular Formula: C15H22O3SSi
• Molecular Weight: 310.489
• Mol file: 777060-75-0.mol

Synonyms:Benzenepropanol, a-[(trimethylsilyl)ethynyl]-, methanesulfonate

Chemical Property of Benzenepropanol, a-[(trimethylsilyl)ethynyl]-, methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanol, a-[(trimethylsilyl)ethynyl]-, methanesulfonate

There total 6 articles about Benzenepropanol, a-[(trimethylsilyl)ethynyl]-, methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-phenyl-1-trimethylsilylpent-1-yn-3-ol (140149-77-5) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid 1-phenethyl-3-trimethylsilanylprop-2-ynyl ester (777060-75-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol0485058

Reference yield:

3-phenyl-propionaldehyde (104-53-0) → methanesulfonic acid 1-phenethyl-3-trimethylsilanylprop-2-ynyl ester (777060-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: nBuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2: triethylamine / CH₂Cl₂ / 3.5 h / 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1039/b610013a

Reference yield:

trimethylsilylacetylene (1066-54-2) → methanesulfonic acid 1-phenethyl-3-trimethylsilanylprop-2-ynyl ester (777060-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: hexane; tetrahydrofuran / 2 h / 0 °C

2.1: 85 percent / Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ol047319z

upstream raw materials:

5-phenyl-1-trimethylsilylpent-1-yn-3-ol

methanesulfonyl chloride

3-phenyl-propionaldehyde

trimethylsilylacetylene

Downstream raw materials:

1-[5,6-bis(trimethylsilyl)hexa-3,4-dienyl]benzene

1-phenyl-5-trimethylsilyl-3,4-nonadiene

(1-(dimethyl(phenyl)silyl)-5-phenylpenta-1,2-dienyl)trimethylsilane

C₁₄H₁₉ClSi