6-Chlorophthalazine

Base Information

Chemical Name:6-Chlorophthalazine
CAS No.:78032-07-2
Molecular Formula:C8H5ClN2
Molecular Weight:164.594
Hs Code.:
DSSTox Substance ID:DTXSID30506646
Nikkaji Number:J3.098.403J
Wikidata:Q82362492

Synonyms:6-chlorophthalazine;78032-07-2;SCHEMBL2228619;DTXSID30506646

Suppliers and Price of 6-Chlorophthalazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
6-chloro-Phthalazine 97.00%
1G
$ 1940.00

Total 0 raw suppliers

Chemical Property of 6-Chlorophthalazine

Chemical Property:

PSA：25.78000
LogP:2.28320
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:164.0141259
Heavy Atom Count:11
Complexity:140

Purity/Quality:: 6-chloro-Phthalazine 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=CN=NC=C2C=C1Cl

Technology Process of 6-Chlorophthalazine

There total 4 articles about 6-Chlorophthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 104-88-1
4-chlorobenzaldehyde

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 78032-07-2
6-chlorophthalazine

Guidance literature:: 4-chlorobenzaldehyde; With n-butyllithium; Bis-(2-methoxyethyl)amine; In tetrahydrofuran; hexane; at -20 ℃; for 0.75h; Inert atmosphere;

With n-butyllithium; In tetrahydrofuran; hexane; at -20 - 0 ℃; for 2.16667h; Inert atmosphere;

N,N-dimethyl-formamide; Further stages;
DOI:10.1021/ol301167q

Reference yield: 20.0%

: 3510-48-3,41097-37-4
N-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-N'-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazine

: 108-90-7
chlorobenzene

: 78032-07-2
6-chlorophthalazine

Guidance literature:: With aluminium trichloride; at 170 - 200 ℃;
DOI:10.1016/0040-4039(81)80093-7

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 78032-07-2
6-chlorophthalazine

Guidance literature:: 4-chlorobenzaldehyde; With n-butyllithium; lithium N-methyl-N-(N',N'-dimethyl-2-aminoethyl)amide; In hexane; at -20 - 20 ℃; for 3h; Inert atmosphere;

With N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.66667h; Inert atmosphere;

With ammonium chloride; hydrazine hydrate; In tetrahydrofuran; hexane; water; at 0 - 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/acs.orglett.5b02003