N-[3-(trifluoromethyl)phenyl]piperidin-4-amine

Base Information

Chemical Name:N-[3-(trifluoromethyl)phenyl]piperidin-4-amine
CAS No.:782446-06-4
Molecular Formula:C12H15F3N2
Molecular Weight:244.26
Hs Code.:
DSSTox Substance ID:DTXSID30406495
Mol file:782446-06-4.mol

Synonyms:N-[3-(trifluoromethyl)phenyl]piperidin-4-amine;782446-06-4;N-(3-(Trifluoromethyl)phenyl)piperidin-4-amine;SCHEMBL1704800;DTXSID30406495;YNGLUJKTMXSDOC-UHFFFAOYSA-N;AKOS003594706

Suppliers and Price of N-[3-(trifluoromethyl)phenyl]piperidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
N-[3-(Trifluoromethyl)phenyl]piperidin-4-amine
500mg
$ 252.00

Crysdot
N-(3-(Trifluoromethyl)phenyl)piperidin-4-amine 97%
5g
$ 796.00

American Custom Chemicals Corporation
N-[3-(TRIFLUOROMETHYL)PHENYL]PIPERIDIN-4-AMINE 95.00%
500MG
$ 854.70

AK Scientific
N-[3-(Trifluoromethyl)phenyl]piperidin-4-amine
500mg
$ 390.00

Total 2 raw suppliers

Chemical Property of N-[3-(trifluoromethyl)phenyl]piperidin-4-amine

Chemical Property:

PSA：24.06000
LogP:3.27110
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:244.11873297
Heavy Atom Count:17
Complexity:236

Purity/Quality:

98%min ^*data from raw suppliers

N-[3-(Trifluoromethyl)phenyl]piperidin-4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC1NC2=CC=CC(=C2)C(F)(F)F

Technology Process of N-[3-(trifluoromethyl)phenyl]piperidin-4-amine

There total 5 articles about N-[3-(trifluoromethyl)phenyl]piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 782446-06-4
4-((3-trifluoromethyl-phenyl)-amino)-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone / N,N-dimethyl-formamide / 70 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401752p

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 782446-06-4
4-((3-trifluoromethyl-phenyl)-amino)-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone / N,N-dimethyl-formamide / 70 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401752p

Reference yield:

: 477864-09-8
tert-butyl 4-((3-(trifluoromethyl)phenyl)amino)piperidine-1-carboxylate

: 782446-06-4
4-((3-trifluoromethyl-phenyl)-amino)-piperidine

Guidance literature:: tert-butyl 4-((3-(trifluoromethyl)phenyl)amino)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In water; pH=14;