1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane

Base Information

Chemical Name:1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane
CAS No.:1089209-93-7
Molecular Formula:C₂₆H₃₄F₃N₃O₄S
Molecular Weight:541.635
Hs Code.:

Synonyms:1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane

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Chemical Property of 1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane

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Technology Process of 1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane

There total 6 articles about 1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.9%

: 1089210-26-3
N-methyl-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofurane-5-sulfonamide

: 782446-06-4
4-((3-trifluoromethyl-phenyl)-amino)-piperidine

: 1089209-93-7
1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane

Guidance literature:: With 1-methyl-pyrrolidin-2-one; triethylamine; at 120 ℃; for 10.5h;

Reference yield:

: 1089210-09-2
7-acetoxy-2,3-dihydro-2,2-dimethyl-benzofuran-5-sulfonyl chloride

: 1089209-93-7
1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 3 h / 5 - 10 °C / Cooling with acetone-dry ice

2: methanol; ammonia; water / 2 h / Heating / reflux

3: sodium methylate / methanol / 40 h / 0 - 5 °C / Heating / reflux

4: 1-methyl-pyrrolidin-2-one; triethylamine / 10.5 h / 120 °C

With 1-methyl-pyrrolidin-2-one; methanol; ammonia; water; sodium methylate; triethylamine; In methanol; ethanol;

Reference yield:

: 1089210-11-6
2,3-dihydro-2,2-dimethyl-7-hydroxy-benzofurane-5-sulfonic acid N-methyl-amide

: 1089209-93-7
1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 40 h / 0 - 5 °C / Heating / reflux

2: 1-methyl-pyrrolidin-2-one; triethylamine / 10.5 h / 120 °C

With 1-methyl-pyrrolidin-2-one; sodium methylate; triethylamine; In methanol;