Tyrphostin AG 1024

Base Information

Chemical Name:Tyrphostin AG 1024
CAS No.:65678-07-1
Molecular Formula:C14H13BrN2O
Molecular Weight:305.174
Hs Code.:2926909090
UNII:NF4XN6A8V9
DSSTox Substance ID:DTXSID50274350
Nikkaji Number:J1.587.963G
Wikidata:Q27074330
Pharos Ligand ID:4M6UM1UP5X9P
ChEMBL ID:CHEMBL2218926
Mol file:65678-07-1.mol

Synonyms:AG 1024;AG-1024;AG1024;tyrphostin AG 1024

Suppliers and Price of Tyrphostin AG 1024

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TyrphostinAG1024
1mg
$ 45.00

Sigma-Aldrich
AG 1024
1mg
$ 85.65

Medical Isotopes, Inc.
TyrphostinAG1024
10 mg
$ 610.00

Matrix Scientific
2-(3-Bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile 95%
1g
$ 4626.00

Matrix Scientific
2-(3-Bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile 95%
100mg
$ 2220.00

DC Chemicals
AG-1024(Tyrphostin) >98%
100 mg
$ 350.00

CSNpharm
AG 1024
5mg
$ 55.00

CSNpharm
AG 1024
1mg
$ 35.00

CSNpharm
AG 1024
10mg
$ 100.00

Crysdot
AG 1024 98+%
10mg
$ 174.00

Total 28 raw suppliers

Chemical Property of Tyrphostin AG 1024

Chemical Property:

Vapor Pressure:2.61E-06mmHg at 25°C
Boiling Point:379.8°Cat760mmHg
Flash Point:183.5°C
PSA：67.81000
Density:1.42g/cm³
LogP:3.88276
Storage Temp.:−20°C
Solubility.:DMSO: soluble
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:304.02113
Heavy Atom Count:18
Complexity:414

Purity/Quality:

99%, ^*data from raw suppliers

TyrphostinAG1024 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O
Description The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM.
Uses Tyrphostin AG 1024 is an insulin-like growth factor (IGF)-I receptor antagonist.

Technology Process of Tyrphostin AG 1024

There total 4 articles about Tyrphostin AG 1024 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65678-06-0
3-bromo-5-tert-butyl-4-hydroxybenzaldehyde

: 109-77-3
malononitrile

: 65678-07-1
2-(3-bromo-5-(tert-butyl)-4-hydroxybenzylidene)malononitrile

Guidance literature:

Reference yield:

: 88-18-6
2-tert-Butylphenol

: 65678-07-1
2-(3-bromo-5-(tert-butyl)-4-hydroxybenzylidene)malononitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; chloroform; water

2: bromine / acetic acid

With sodium hydroxide; bromine; In methanol; chloroform; water; acetic acid;