Propanedioic acid, [(cyclohexylamino)methylene]-, diethyl ester

Base Information

Chemical Name:Propanedioic acid, [(cyclohexylamino)methylene]-, diethyl ester
CAS No.:78596-46-0
Molecular Formula:C14H23NO4
Molecular Weight:269.341
Hs Code.:
DSSTox Substance ID:DTXSID10452713

Synonyms:78596-46-0;Propanedioic acid, [(cyclohexylamino)methylene]-, diethyl ester;DTXSID10452713

Suppliers and Price of Propanedioic acid, [(cyclohexylamino)methylene]-, diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, [(cyclohexylamino)methylene]-, diethyl ester

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:269.16270821
Heavy Atom Count:19
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=CNC1CCCCC1)C(=O)OCC

Technology Process of Propanedioic acid, [(cyclohexylamino)methylene]-, diethyl ester

There total 4 articles about Propanedioic acid, [(cyclohexylamino)methylene]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-91-8,157973-60-9
cyclohexylamine

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 78596-46-0
ethyl 3-cyclohexylamino-2-ethoxycarbonylacrylate

Guidance literature:: In methanol; for 0.25h; Ambient temperature;
DOI:10.1055/s-1983-30587

Reference yield: 85.0%

: 226881-99-8
2-(2,2,2-trichloro-1-cyclohexylamino-ethyl)-malonic acid diethyl ester

: 78596-46-0
ethyl 3-cyclohexylamino-2-ethoxycarbonylacrylate

Guidance literature:: With PEG-400; potassium carbonate; In acetonitrile; Heating;
DOI:10.1080/00397919908086168

Reference yield:

: 27971-92-2
diethyl 2,2,2-trichloroethylidenepropanedioate

: 78596-46-0
ethyl 3-cyclohexylamino-2-ethoxycarbonylacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / acetonitrile / 1 h / Heating

2: 85 percent / K₂CO₃, PEG-400 / acetonitrile / Heating

With PEG-400; potassium carbonate; In acetonitrile;
DOI:10.1080/00397919908086168