Chemical Property of Ketorolac
Chemical Property:
- Appearance/Colour:white crystalline or white powder
- Vapor Pressure:1.52E-10mmHg at 25°C
- Melting Point:160-161 ºC
- Refractive Index:1.659
- Boiling Point:223.7 ºC at 760 mmHg
- PKA:3.49 ±0.02(at 25℃)
- Flash Point:89.1 ºC
- PSA：59.30000
- Density:1.398 g/cm3
- LogP:2.29100
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Slightly), Methanol (Slightly)
- Water Solubility.:183mg/L(32 oC)
- XLogP3:1.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:255.08954328
- Heavy Atom Count:19
- Complexity:376
- Purity/Quality:
-
99% *data from raw suppliers
racKetorolac *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Nonsteroidal Antiinflammatory Drugs
- Canonical SMILES:C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O
- Recent ClinicalTrials:Dosing of Ketorolac Impacts Post-cesarean paiN manaGemenet (KING)
- Recent EU Clinical Trials:Effectiveness of Periocular drug Injection in CATaract surgery
- Recent NIPH Clinical Trials:The usefulness of dual channel elastomeric pump for intravenous patient-controlled analgesia in geriatrics underwent gastrointestinal tumor surgery : a randomized, double-blind, prospective study
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Uses
antiarrhythmic prostaglandin F2a analogue Ketorolac-d5 is a labeled analogue of Ketorolac, a Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
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Indications
Ketorolac (Toradol), an NSAID chemically related
to indomethacin and tolmetin, is mainly used as an analgesic,
not for the treatment of inflammatory disease. It
is available in oral, parenteral, and topical formulations.
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Biological Functions
Ketorolac (Toradol) is an NSAID with very mild antiinflammatory
and antipyretic activity. It is a potent analgesic
for postoperative pain. Its efficacy is equivalent to
that of low doses of morphine in the control of pain. For
this reason it is often combined with opioids to reduce
opioid dose and related side effects while providing adequate
pain relief. It is also used to replace the opioids in
some patients with opioid sensitivity. The mechanism of
action of ketorolac involves the inhibition of COX and
decreased formation of prostaglandins. However, some
evidence exists that ketorolac may stimulate the release
of endogenous opioids as a part of its analgesic activity.
