2-Ethoxy-1-fluoronaphthalene

Base Information

• Chemical Name: 2-Ethoxy-1-fluoronaphthalene
• CAS No.: 78649-26-0
• Molecular Formula: C₁₂H₁₁FO
• Molecular Weight: 190.217
• Mol file: 78649-26-0.mol

Synonyms:2-Ethoxy-1-fluoronaphthalene;

Chemical Property of 2-Ethoxy-1-fluoronaphthalene

Chemical Property:

• PSA: 9.23000
• LogP: 3.37760

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethoxy-1-fluoronaphthalene

There total 3 articles about 2-Ethoxy-1-fluoronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-ethoxynaphthalene (93-18-5) → 1-fluoro-2-ethoxynaphthalene (78649-26-0)

Guidance literature:

With N-fluorobis(benzenesulfon)imide; at 85 - 90 ℃;

DOI:10.1016/j.tetlet.2007.02.077

Reference yield: 50.0%

2-ethoxynaphthalene (93-18-5) → 1,1-difluoro-1H-naphthalen-2-one (51417-64-2) + 1-fluoro-2-ethoxynaphthalene (78649-26-0)

Guidance literature:

With cesium fluoroxysulphate; boron trifluoride; In acetonitrile; for 0.5h; Ambient temperature;

DOI:10.1021/jo00219a032

Reference yield:

(2-ethoxynaphthalen-1-yl)boronic acid (148345-64-6) → 1-fluoro-2-ethoxynaphthalene (78649-26-0)

Guidance literature:

(2-ethoxynaphthalen-1-yl)boronic acid; With silver trifluoromethanesulfonate; sodium hydroxide; In methanol;

With CF₃O₃S^(1-)*C₂₅H₂₀BFN₉Pd⁽¹⁺⁾; bathophenanthroline; silver trifluoromethanesulfonate; In acetonitrile; at 90 ℃;

DOI:10.1039/c3sc52367e

upstream raw materials:

2-ethoxynaphthalene

(2-ethoxynaphthalen-1-yl)boronic acid

Refernces

• 1、 Stavber, Gaj,Zupan, Marko,Stavber, Stojan. "Solvent-free fluorination of organic compounds using N-F reagents". . p. 2671 - 2673. Retrieved 2008/02/03.
• 2、 Stavber, Stojan,Zupan, Marko. "Caesium Fluoroxysulphate as a Mild Fluorinating Agent for the Fluorination of Alkoxy-substituted Benzene and Naphthalene Derivatives". . p. 148. Retrieved 2007/10/02.