5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
CAS No.:79085-71-5
Molecular Formula:C10H11BrFN
Molecular Weight:244.106
Hs Code.:
DSSTox Substance ID:DTXSID00512512
Mol file:79085-71-5.mol

Synonyms:5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline;79085-71-5;5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine;SCHEMBL10841291;DTXSID00512512;XHAXMUHHFPDPDH-UHFFFAOYSA-N;(S)-5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline;MFCD22581295;MFCD29077642;AT35194;118665-09-1;SY343603;SY343604

Suppliers and Price of 5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Chemical Property:

PSA：12.03000
LogP:3.47280
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:243.00589
Heavy Atom Count:13
Complexity:188

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCC2=C(N1)C=CC(=C2Br)F

Technology Process of 5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

There total 2 articles about 5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 80290-18-2
5-bromo-6-fluoro-2-methylquinoline

: 79085-71-5
5-bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid;
DOI:10.1002/jhet.5570290436

Reference yield:

: 1128-61-6
6-fluoro-2-methyl-quinoline

: 79085-71-5
5-bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Br₂, Ag₂SO₄, cc H₂SO₄, / 1 h

2: 68 percent / H₂, / PtO₂, / acetic acid / Ambient temperature

With sulfuric acid; hydrogen; bromine; silver sulfate; platinum(IV) oxide; In acetic acid;
DOI:10.1248/cpb.37.2103

Reference yield:

: 79085-71-5
5-bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

: 124858-35-1,81962-84-7
nadifloxacin

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) PPA, 3.) cc HCl, / 1.) 150 deg C, 1 h, 2.) 150 deg C, 30 min, 3.) AcOH, H₂O, reflux, 2 h,

2: 25 percent / hexamethylphosphoric acid triamide / 7 h / 160 °C

With hydrogenchloride; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1248/cpb.37.2103