METHYL 2-(2-FORMYL-1H-PYRROL-1-YL)BENZOATE

Base Information

• Chemical Name: METHYL 2-(2-FORMYL-1H-PYRROL-1-YL)BENZOATE
• CAS No.: 79100-16-6
• Molecular Formula: C13H11NO3
• Molecular Weight: 229.235
• Mol file: 79100-16-6.mol

Synonyms:methyl 2-(2-formyl-1H-pyrrol-1-yl)benzenecarboxylate;3-(5-thioxo-4,5-dihydro-tetrazol-1-yl)-propionic acid methyl ester;1-(2-methoxycarbonylphenyl)pyrrole-2-carboxaldehyde;N-(2-methoxycarbonylphenyl)pyrrole-2-carboxaldehyde;1-(2-metossicarbonilfenil)pirrolo-2-carbossaldeide;1-(2-Methoxycarbonylethyl)-tetrazol-5-thiol;1H-Tetrazole-1-propanoic acid,2,5-dihydro-5-thioxo-,methyl ester;

Chemical Property of METHYL 2-(2-FORMYL-1H-PYRROL-1-YL)BENZOATE

Chemical Property:

• PSA: 48.30000
• LogP: 2.07640

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-(2-Formyl-1H-pyrrol-1-yl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-(2-FORMYL-1H-PYRROL-1-YL)BENZOATE

There total 3 articles about METHYL 2-(2-FORMYL-1H-PYRROL-1-YL)BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (65057-97-8) + 2-carbomethoxyaniline (134-20-3) → methyl 2-(2-formyl-1H-pyrrol-1-yl)benzenecarboxylate (79100-16-6)

Guidance literature:

With acetic acid; for 3h; Reflux;

DOI:10.3987/COM-08-11436

Reference yield: 59.0%

methyl 2-(1H-pyrrol-1-yl)benzoate (10333-67-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → methyl 2-(2-formyl-1H-pyrrol-1-yl)benzenecarboxylate (79100-16-6)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 0 ℃; for 0.75h; Inert atmosphere;

methyl 2-(1H-pyrrol-1-yl)benzoate; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03672

Reference yield:

o-iodo-methyl-benzoic acid (610-97-9) → methyl 2-(2-formyl-1H-pyrrol-1-yl)benzenecarboxylate (79100-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide; potassium phosphate; 1,10-Phenanthroline / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

2.1: trichlorophosphate / 0.75 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline; trichlorophosphate; In 1,4-dioxane; 2.1: |Vilsmeier-Haack Formylation / 2.2: |Vilsmeier-Haack Formylation;

DOI:10.1021/acs.orglett.5b03672

upstream raw materials:

methyl 2-(1H-pyrrol-1-yl)benzoate

N,N-dimethyl-formamide

tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal

2-carbomethoxyaniline

Downstream raw materials:

C₂₂H₂₄N₂O₄

5-(3,4-dimethoxybenzyl)-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 79100-16-6 METHYL 2-(2-FORMYL-1H-PYRROL-1-YL)BENZOATE

Send

Send

Metric Ton KG G Pound L ML

Send

Send