3-Thiomorpholinecarboxylic acid, methyl ester, (R)-

Base Information

• Chemical Name: 3-Thiomorpholinecarboxylic acid, methyl ester, (R)-
• CAS No.: 79161-91-4
• Molecular Formula: C₆H₁₁NO₂S
• Molecular Weight: 161.225
• Mol file: 79161-91-4.mol

Synonyms:

Chemical Property of 3-Thiomorpholinecarboxylic acid, methyl ester, (R)-

Chemical Property:

• PSA: 63.63000
• LogP: 0.19320

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Thiomorpholinecarboxylic acid, methyl ester, (R)-

There total 7 articles about 3-Thiomorpholinecarboxylic acid, methyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-cysteine methyl ester hydrochloride (18598-63-5) + diisopropyl(vinyl)sulfonium trifluoromethanesulfonate → methyl (3R)-1,4-thiazane-3-carboxylate (78865-47-1,79161-91-4,104254-25-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 15h;

DOI:10.1002/anie.200800373

Reference yield: 96.0%

L-cysteine methyl ester hydrochloride (18598-63-5) + diphenyl(vinyl)sulfonium trifluoromethanesulfonate → methyl (3R)-1,4-thiazane-3-carboxylate (78865-47-1,79161-91-4,104254-25-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 15h;

DOI:10.1002/anie.200800373

Reference yield: 92.0%

L-cysteine methyl ester hydrochloride (18598-63-5) + (vinylselenonyl)benzene → methyl (3R)-1,4-thiazane-3-carboxylate (78865-47-1,79161-91-4,104254-25-3)

Guidance literature:

L-cysteine methyl ester hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

(vinylselenonyl)benzene; In dichloromethane; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1002/chem.201002593

upstream raw materials:

2-amino-3-(2-chloro-ethylsulfanyl)-propionic acid methyl ester hydrochloride

1-vinyltetrahydro-1H-thiophenium trifluoromethanesulfonate

L-cysteine methyl ester hydrochloride

methanol

Refernces

• 1、 Bagnoli, Luana,Scarponi, Catalina,Rossi, Maria Giovanna,Testaferri, Lorenzo,Tiecco, Marcello. "Synthesis of enantiopure 1,4-dioxanes, morpholines, and piperazines from the reaction of chiral 1,2-diols, amino alcohols, and diamines with vinyl selenones". supporting information; experimental part. p. 993 - 999. Retrieved 2011/03/20.
• 2、 -. "Substituted 6?membered n?heterocyclic compounds and their uses as neurological regulator". Page/Page column 6. . Retrieved 2008/06/13.