5-Methoxy-2-methylquinoline

Base Information

• Chemical Name: 5-Methoxy-2-methylquinoline
• CAS No.: 79205-04-2
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID70462590
• Nikkaji Number: J2.152.445J
• Wikidata: Q82287145
• Mol file: 79205-04-2.mol

Synonyms:5-Methoxy-2-methylquinoline;79205-04-2;5-methoxy-2-methyl-quinoline;SCHEMBL2757271;DTXSID70462590;OQPWQOOLGQWRAL-UHFFFAOYSA-N;MFCD18452218;AKOS016004286;SB67654;AS-59159;CS-0036279;FT-0754502;EN300-132952;A849441;Z1258981800

Chemical Property of 5-Methoxy-2-methylquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 2.55180
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-2-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(C=C1)C(=CC=C2)OC

Technology Process of 5-Methoxy-2-methylquinoline

There total 10 articles about 5-Methoxy-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

8-chloro-5-methoxy-2-methylquinoline hydrochloride → 5-methoxy-2-methylquinoline (79205-04-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In methanol; at 20 ℃; under 1034.32 Torr;

DOI:10.1021/op300185s

Reference yield: 94.0%

5-bromo-2-methylquinoline (54408-52-5) → 5-methoxy-2-methylquinoline (79205-04-2)

Guidance literature:

for 8h; Heating; methoxylation;

DOI:10.1248/cpb.29.1615

Reference yield: 78.0%

ethanol (64-17-5) + 2-methoxy-phenylamine (90-04-0) → 5-methoxy-2-methylquinoline (79205-04-2)

Guidance literature:

With gold on titanium oxide; at 30 ℃; for 4h; UV-irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.071

upstream raw materials:

5-bromo-2-methylquinoline

trans-Crotonaldehyde

m-Anisidine

crotonaldehyde

Downstream raw materials:

(4aS,1'S)-7-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-1-one

(4aR,1'S)-7-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-1-one

(4aS,1'S)-7-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline

(4aR,1'S)-7-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline