1H-Pyrrole-2-acetic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-3-(methoxycarbonyl)-4-methyl-, phenylmethyl ester

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Chemical Name:1H-Pyrrole-2-acetic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-3-(methoxycarbonyl)-4-methyl-, phenylmethyl ester
CAS No.:79264-60-1
Molecular Formula:C₂₉H₃₆N₂O₆
Molecular Weight:508.615
Hs Code.:

1H-Pyrrole-2-acetic acid,
5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth
yl]-3-(methoxycarbonyl)-4-methyl-, phenylmethyl ester

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Chemical Property of 1H-Pyrrole-2-acetic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-3-(methoxycarbonyl)-4-methyl-, phenylmethyl ester

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Technology Process of 1H-Pyrrole-2-acetic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-3-(methoxycarbonyl)-4-methyl-, phenylmethyl ester

There total 7 articles about 1H-Pyrrole-2-acetic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-3-(methoxycarbonyl)-4-methyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.4%

: 82448-72-4
tert-butyl 5-acetoxymethyl-4-ethyl-3-methylpyrrole-2-carboxylate

: 95305-24-1
methyl 2-benzyloxycarbonylmethyl-4-methylpyrrole-3-carboxylate

: 95305-25-2
di-t-butyl 3,3'-diethyl-4,4'-dimethyl-2,2'-pyrromethane-5,5'-dicarboxylate

: 79264-60-1
5-t-butyl 4'-methyl 5'-benzyloxycarbonylmethyl-4,3'-dimethyl-3-ethyl-2,2'-pyrromethane-5,4'-dicarboxylate

: 95305-26-3
dimethyl 5,5'-bisbenzyloxycarbonylmethyl-3,3'-dimethyl-2,2'-pyrromethane-4,4'-dicarboxylate

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; for 0.166667h;
DOI:10.1039/P19840002733

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 79264-60-1
5-t-butyl 4'-methyl 5'-benzyloxycarbonylmethyl-4,3'-dimethyl-3-ethyl-2,2'-pyrromethane-5,4'-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium nitrite, 2.) zinc dust, sodium acetate / 1.) water, glacial acetic acid, 20 deg C, overnight, 2.) 70 - 80 deg C, 1 h

2: 94 percent / H₂ / palladium on charcoal / methanol; tetrahydrofuran / 5 h

3: 88 percent / aq. sodium hydrogen carbonate, iodine, potassium iodide / CHCl₃; H₂O / 0.25 h

4: H₂, sodium acetate / palladium on charcoal / methanol / 6 h

5: 68.4 percent / sulphuric acid / tetrahydrofuran / 24 h / 20 °C

6: 67.4 percent / toluene-p-sulphonic acid / CH₂Cl₂ / 0.17 h

With sulfuric acid; hydrogen; iodine; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; potassium iodide; zinc; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;
DOI:10.1039/P19840002733

Reference yield:

: 95305-23-0
methyl 5-iodo-2-methoxycarbonylmethyl-4-methylpyrrole-3-carboxylate

: 79264-60-1
5-t-butyl 4'-methyl 5'-benzyloxycarbonylmethyl-4,3'-dimethyl-3-ethyl-2,2'-pyrromethane-5,4'-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂, sodium acetate / palladium on charcoal / methanol / 6 h

2: 68.4 percent / sulphuric acid / tetrahydrofuran / 24 h / 20 °C

3: 67.4 percent / toluene-p-sulphonic acid / CH₂Cl₂ / 0.17 h

With sulfuric acid; hydrogen; sodium acetate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/P19840002733