2,2-Diphenyl-1-[5-(trimethylsilyl)-2-thiazolyl]ethanone

Base Information

• Chemical Name: 2,2-Diphenyl-1-[5-(trimethylsilyl)-2-thiazolyl]ethanone
• CAS No.: 79265-37-5
• Molecular Formula: C20H21NOSSi
• Molecular Weight: 351.544
• DSSTox Substance ID: DTXSID601206213

Synonyms:2,2-Diphenyl-1-[5-(trimethylsilyl)-2-thiazolyl]ethanone;DTXSID601206213;79265-37-5

Chemical Property of 2,2-Diphenyl-1-[5-(trimethylsilyl)-2-thiazolyl]ethanone

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 351.11131200
• Heavy Atom Count: 24
• Complexity: 406

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C[Si](C)(C)C1=CN=C(S1)C(=O)C(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2,2-Diphenyl-1-[5-(trimethylsilyl)-2-thiazolyl]ethanone

There total 2 articles about 2,2-Diphenyl-1-[5-(trimethylsilyl)-2-thiazolyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(2,2-Diphenyl-1-trimethylsilanyloxy-vinyl)-5-trimethylsilanyl-thiazole (79265-35-3) → 2,2-Diphenyl-1-(5-trimethylsilanyl-thiazol-2-yl)-ethanone (79265-37-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jo00243a029

Reference yield: 89.0%

2,5-bis-trimethylsilanyl-thiazole (79265-34-2) + diphenyl ketene (525-06-4) → 2,2-Diphenyl-1-(5-trimethylsilanyl-thiazol-2-yl)-ethanone (79265-37-5)

Guidance literature:

Reference yield: 45.0%

butyraldehyde (123-72-8) + 2,2-Diphenyl-1-(5-trimethylsilanyl-thiazol-2-yl)-ethanone (79265-37-5) → 1-[5-(1-Hydroxy-butyl)-thiazol-2-yl]-2,2-diphenyl-ethanone (112970-11-3)

Guidance literature:

With cesium fluoride; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1021/jo00243a029

upstream raw materials:

2,5-bis-trimethylsilanyl-thiazole

diphenyl ketene

2-(2,2-Diphenyl-1-trimethylsilanyloxy-vinyl)-5-trimethylsilanyl-thiazole

Downstream raw materials:

1-[5-(1-Hydroxy-butyl)-thiazol-2-yl]-2,2-diphenyl-ethanone

2,2-Diphenyl-1-thiazol-2-yl-ethanone

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