1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-
CAS No.:794479-71-3
Molecular Formula:C34H38ClF3N4O2
Molecular Weight:627.15
Hs Code.:

1-Pyrrolidinecarboxamide,
N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[
4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-

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Chemical Property of 1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-

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Technology Process of 1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-

There total 7 articles about 1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 762285-68-7
4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-(S)-pyrrolidin-3-yl-amide

: C₂₁H₂₄ClN₃O₄

: 794479-71-3
(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid {(R)-1-[3-(4-chloro-phenyl)-propyl]-pyrrolidin-3-yl}-methyl-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 20h; Heating / reflux;

Reference yield:

: 195457-71-7
4-[4-(trifluoromethyl)phenyl]benzoic acid

: 762285-95-0
(S)-3-Methylamino-pyrrolidine-1-carboxylic acid {(R)-1-[3-(4-chloro-phenyl)-propyl]-pyrrolidin-3-yl}-methyl-amide

: 794479-71-3
(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid {(R)-1-[3-(4-chloro-phenyl)-propyl]-pyrrolidin-3-yl}-methyl-amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

Reference yield:

: 144043-17-4
(3R)-1-benzyl-N-methylpyrrolidin-3-amine

: 794479-71-3
(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid {(R)-1-[3-(4-chloro-phenyl)-propyl]-pyrrolidin-3-yl}-methyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran

2: dimethylformamide / 100 °C

3: ammonium formate / Pd/C / ethanol / Heating

4: NaBH₃CN / methanol

5: TFA / CH₂Cl₂

6: CH₂Cl₂

With ammonium formate; sodium cyanoborohydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.12.036