2-Nonyn-1-al diethyl acetal

Base Information

• Chemical Name: 2-Nonyn-1-al diethyl acetal
• CAS No.: 79496-57-4
• Molecular Formula: C13H24O2
• Molecular Weight: 212.332
• Mol file: 79496-57-4.mol

Synonyms:1,1-Diaethoxy-non-2-in;2-NONYNAL DIETHYL ACETAL/1,1 -DIETHOXY-2-NONYNE;n-Hexyl-propiolaldehyd-diaethylacetal;Non-2-inal-diaethylacetal;non-2-ynal-diethylacetal;1,1-diethoxynon-2-yne;

Chemical Property of 2-Nonyn-1-al diethyl acetal

Chemical Property:

• PSA: 18.46000
• LogP: 3.35930

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Nonyn-1-al diethyl acetal

There total 7 articles about 2-Nonyn-1-al diethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.3%

n-octyne (629-05-0) + orthoformic acid triethyl ester (122-51-0) → Non-2-yn-1-al diethyl acetal (79496-57-4)

Guidance literature:

With sodium iodide; zinc(II) chloride; for 5h; Heating;

DOI:10.1021/jo00363a043

Reference yield: 70.0%

non-2-ynal (1846-69-1) + orthoformic acid triethyl ester (122-51-0) → Non-2-yn-1-al diethyl acetal (79496-57-4)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 20 ℃; for 29h;

DOI:10.1016/j.tet.2003.08.068

Reference yield:

n-octyne (629-05-0) → Non-2-yn-1-al diethyl acetal (79496-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; HMPA / tetrahydrofuran; hexane / 0.58 h / -60 - -35 °C

1.2: 84 percent / hexane; tetrahydrofuran / 2.17 h / -65 - -16 °C

2.1: 70 percent / p-toluenesulfonic acid monohydrate / ethanol / 29 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; hexane;

DOI:10.1016/j.tet.2003.08.068

upstream raw materials:

methyl magnesium iodide

n-octyne

ethylmagnesium bromide

3-chloropropargyl aldehyde diethyl acetal

Downstream raw materials:

(E)-1,1-diethoxy-3-phenylsulphinylnon-2-ene

pelargonaldehyde diethyl acetal

1,1-diethoxy-non-2-ene

2-(Benzotriazol-1-yl)-2-ethoxy-1-hydroxy-1-phenyl-3-decyne