4-Thiazoleacetic acid, 2-[(chloroacetyl)amino]-, diphenylmethyl ester

Base Information

• Chemical Name: 4-Thiazoleacetic acid, 2-[(chloroacetyl)amino]-, diphenylmethyl ester
• CAS No.: 79540-64-0
• Molecular Formula: C₂₀H₁₇ClN₂O₃S
• Molecular Weight: 400.886
• Mol file: 79540-64-0.mol

Synonyms:

Chemical Property of 4-Thiazoleacetic acid, 2-[(chloroacetyl)amino]-, diphenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Thiazoleacetic acid, 2-[(chloroacetyl)amino]-, diphenylmethyl ester

There total 2 articles about 4-Thiazoleacetic acid, 2-[(chloroacetyl)amino]-, diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(2-chloroacetamidothiazol-4-yl)acetic acid (65243-18-7) + diazodiphenylmethane (908093-98-1) → 2-Chloroacetamido-4-diphenylmethoxycarbonylmethylthiazole (79540-64-0)

Guidance literature:

In acetonitrile; for 4h; Ambient temperature;

DOI:10.1002/jhet.5570210435

Reference yield:

2-chloroacetamido-4-thiazolyl acetic acid ethyl ester (19749-93-0) → 2-Chloroacetamido-4-diphenylmethoxycarbonylmethylthiazole (79540-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 2N aq. NaOH / ethanol / 3 h

2: 73 percent / acetonitrile / 4 h / Ambient temperature

With sodium hydroxide; In ethanol; acetonitrile;

DOI:10.1002/jhet.5570210435

Reference yield: 64.0%

2-Chloroacetamido-4-diphenylmethoxycarbonylmethylthiazole (79540-64-0) → 2-Chloroacetamido-4-diphenylmethoxycarbonylmethylthiazole N-Oxide (94417-82-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 48h;

DOI:10.1002/jhet.5570210435

upstream raw materials:

2-(2-chloroacetamidothiazol-4-yl)acetic acid

diazodiphenylmethane

2-chloroacetamido-4-thiazolyl acetic acid ethyl ester

Downstream raw materials:

2-Chloroacetamido-4-diphenylmethoxycarbonylmethylthiazole N-Oxide