ETHYL 2-(2-CHLOROACETAMIDO)-4-THIAZOLEACETATE

Base Information

• Chemical Name: ETHYL 2-(2-CHLOROACETAMIDO)-4-THIAZOLEACETATE
• CAS No.: 19749-93-0
• Molecular Formula: C9H11 Cl N2 O3 S
• Molecular Weight: 262.717
• Hs Code.: 2934100090
• Mol file: 19749-93-0.mol

Synonyms:4-Thiazoleaceticacid, 2-(2-chloroacetamido)-, ethyl ester (8CI); 4-Thiazoleacetic acid, 2-[(chloroacetyl)amino]-,ethyl ester (9CI); 2-(Chloroacetamido)-4-(ethoxycarbonylmethyl)-1,3-thiazole;Ethyl 2-(2-chloroacetamido)-4-thiazoleacetate

Chemical Property of ETHYL 2-(2-CHLOROACETAMIDO)-4-THIAZOLEACETATE

Chemical Property:

• Melting Point: 146-148 °C(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 96.53000
• Density: 1.413g/cm³
• LogP: 1.49900

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl{2-[(Chloroacetyl)amino]-1,3-thiazol-4-yl}acetate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of ETHYL 2-(2-CHLOROACETAMIDO)-4-THIAZOLEACETATE

There total 9 articles about ETHYL 2-(2-CHLOROACETAMIDO)-4-THIAZOLEACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) + chloroacetyl chloride (79-04-9) → 2-chloroacetamido-4-thiazolyl acetic acid ethyl ester (19749-93-0)

Guidance literature:

ethyl 2-amino-1,3-thiazol-4-acetate; With triethylamine; In dichloromethane; for 0.5h; Cooling with ice;

chloroacetyl chloride; In dichloromethane; for 4h;

Reference yield:

[4-(2-Amino-thiazol-4-yl)-phenyl]-acetic acid ethyl ester (122352-22-1) + chloroacetyl chloride (79-04-9) → 2-chloroacetamido-4-thiazolyl acetic acid ethyl ester (19749-93-0)

Guidance literature:

[4-(2-Amino-thiazol-4-yl)-phenyl]-acetic acid ethyl ester; With potassium carbonate; In dichloromethane; at 20 ℃; for 0.5h;

chloroacetyl chloride; In dichloromethane; at 20 ℃; Cooling with ice; Reflux;

DOI:10.1016/j.bmc.2015.05.027

Reference yield:

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) + Chloroacetic anhydride (541-88-8) → 2-(2-Chloroacetylimino-4-thiazolin-4-yl)-acetic acid ethyl ester (19749-93-0)

Guidance literature:

With pyridine; In dichloromethane;

upstream raw materials:

ethyl 2-amino-1,3-thiazol-4-acetate

chloroacetyl chloride

4-(4-methoxyphenyl)-1,3-thiazol-2-amine

ethyl 2-bromoacetoacetate

Downstream raw materials:

2-(2-chloroacetamidothiazol-4-yl)acetic acid

2-(2-chloroacetamido-4-thiazolyl)-(Z)-2-[1-methyl-1-(p-nitrobenzyloxycarbonyl)ethyloxyimino]acetic acid

cis-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

Refernces

• 1、 Xiao, Mengwu,Xu, Lvjie,Lin, Ding,Lian, Wenwen,Cui, Manying,Zhang, Meng,Yan, Xiaowei,Li, Shuishi,Zhao, Jun,Ye, Jiao,Liu, Ailin,Hu, Aixi. "Design, synthesis, and bioassay of 4-thiazolinone derivatives as influenza neuraminidase inhibitors". . . Retrieved 2021/02/09.
• 2、 Valiveti, Aditya Kapil,Bhalerao, Uma M.,Acharya, Jyotiranjan,Karade, Hitendra N.,Acharya, Badri Narayan,Raviraju,Halve, Anand K.,Kaushik, Mahabir Parshad. "Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE)". . p. 4899 - 4910. Retrieved 2015/08/03.