Technology Process of 1H-Imidazole-4-carboxylic acid,
1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-ethyl-, ethyl ester
There total 5 articles about 1H-Imidazole-4-carboxylic acid,
1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-ethyl-, ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-bromo-2-oxo-pentanoic acid ethyl ester; 2,4-dichloro-N-(4-chlorophenyl)benzenecarboximidamide;
With
sodium hydrogencarbonate;
In
isopropyl alcohol;
for 20h;
Heating;
With
trifluoroacetic acid;
In
isopropyl alcohol;
for 16h;
Heating;
DOI:10.1021/jm040843r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 100 percent / Br2
2.1: NaHCO3 / propan-2-ol / 20 h / Heating
2.2: 65 percent / TFA / propan-2-ol / 16 h / Heating
With
bromine; sodium hydrogencarbonate;
In
isopropyl alcohol;
DOI:10.1021/jm040843r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 84 percent / sodium hexamethyldisilazanide / tetrahydrofuran / 16 h / 20 °C
2.1: NaHCO3 / propan-2-ol / 20 h / Heating
2.2: 65 percent / TFA / propan-2-ol / 16 h / Heating
With
sodium hexamethyldisilazane; sodium hydrogencarbonate;
In
tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm040843r
