Methyl 3-(3-phenylpiperidin-3-yl)propanoate

Base Information

• Chemical Name: Methyl 3-(3-phenylpiperidin-3-yl)propanoate
• CAS No.: 79950-36-0
• Molecular Formula: C15H21NO2
• Molecular Weight: 247.337
• DSSTox Substance ID: DTXSID40507366
• Mol file: 79950-36-0.mol

Synonyms:methyl 3-(3-phenylpiperidin-3-yl)propanoate;79950-36-0;SCHEMBL13211303;DTXSID40507366;FT-0745921

Chemical Property of Methyl 3-(3-phenylpiperidin-3-yl)propanoate

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 247.157228913
• Heavy Atom Count: 18
• Complexity: 274

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CCC1(CCCNC1)C2=CC=CC=C2

Technology Process of Methyl 3-(3-phenylpiperidin-3-yl)propanoate

There total 8 articles about Methyl 3-(3-phenylpiperidin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-oxo-3-phenylpiperidine-3-propanoic acid methyl ester (95062-70-7) → 3-(3-Phenyl-piperidin-3-yl)-propionic acid methyl ester (79950-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 7 h / Ambient temperature

2: NaBH₄ / ethanol / 1.) 0 deg C, 1 h, 2.) room temperature, 4 h

With sodium tetrahydroborate; In ethanol; dichloromethane;

Reference yield:

dimethyl 4-cyano-4-phenylheptanedioate (38289-18-8) → 3-(3-Phenyl-piperidin-3-yl)-propionic acid methyl ester (79950-36-0)

Guidance literature:

Multi-step reaction with 2 steps

2: 2) Borch reduction

DOI:10.1039/c39810000814

Reference yield:

6-oxo-3-phenylpiperidine-3-propanoic acid (79950-35-9) → 3-(3-Phenyl-piperidin-3-yl)-propionic acid methyl ester (79950-36-0)

Guidance literature:

Multi-step reaction with 3 steps

2: CH₂Cl₂ / 7 h / Ambient temperature

3: NaBH₄ / ethanol / 1.) 0 deg C, 1 h, 2.) room temperature, 4 h

With sodium tetrahydroborate; In ethanol; dichloromethane;

upstream raw materials:

diazomethane

6-oxo-3-phenylpiperidine-3-propanoic acid

methyl 3-phenyl-6-thioxopiperidine-3-propionate

dimethyl 4-cyano-4-phenylheptanedioate

Downstream raw materials:

5-phenyl-1-azabicyclo<3.3.1>nonan-2-one

C₂₂H₂₅ClN₂O₃