2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide

Base Information

• Chemical Name: 2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide
• CAS No.: 66604-68-0
• Molecular Formula: C18H17N2+
• Molecular Weight: 388.251
• Mol file: 66604-68-0.mol

Synonyms:

Chemical Property of 2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide

Chemical Property:

• Vapor Pressure: 1.3E-09mmHg at 25°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide

There total 7 articles about 2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-methyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium iodide (91653-18-8) → 2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide (66604-68-0)

Guidance literature:

2-methyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium iodide; With sodium bis(2-methoxyethoxy)aluminium dihydride; In 5,5-dimethyl-1,3-cyclohexadiene; toluene; at 130 ℃; for 6h;

With 3-ethoxycarbonyl-1-methylpyridinium chloride; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2014.05.032

Reference yield: 73.0%

ellipticine (519-23-3) + methyl iodide (74-88-4) → 2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide (66604-68-0)

Guidance literature:

In acetone; for 48h; Darkness;

DOI:10.1016/j.bmc.2011.07.020

Reference yield:

indole (120-72-9) → 2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide (66604-68-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / ethanol / 1.5 h / Reflux

2.1: trichlorophosphate / 1,2-dichloro-benzene / 1.5 h / 20 °C

2.2: 4 h / 105 °C

2.3: 20 °C

3.1: 3 h / 115 °C / Inert atmosphere

3.2: 1 h / 20 °C / Molecular sieve; Inert atmosphere

4.1: sodium carbonate; p-toluenesulfonyl chloride / tetrahydrofuran; water / 2 h / 20 °C

4.2: 12 h

4.3: 0 °C / pH 10

5.1: acetone / 48 h / Darkness

With sodium carbonate; toluene-4-sulfonic acid; p-toluenesulfonyl chloride; trichlorophosphate; In tetrahydrofuran; ethanol; water; 1,2-dichloro-benzene; acetone; 2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction;

DOI:10.1016/j.bmc.2011.07.020

upstream raw materials:

2-methyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium iodide

2,11-Dimethyl-2,6-dihydro-1H-pyrido[4,3-b]carbazole-5-carboxylic acid methyl ester

indole

1,4-dimethyl-9H-carbazole

Downstream raw materials:

ellipticine