Technology Process of Benzene, 4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)-
There total 15 articles about Benzene, 4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[4-cyclohexyl-3-(trifluoromethyl)phenyl]methanol;
With
hydrogen bromide; acetic acid;
In
toluene;
at 20 - 25 ℃;
for 0.166667h;
With
acetic anhydride;
In
toluene;
at 20 - 25 ℃;
for 21h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; sodium methylate / methanol / 100 °C
2.1: hydrogen; 5%-palladium/activated carbon / methanol / 16 h / 60 °C / 3750.38 Torr
3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / n-heptane; acetonitrile / 80 °C
4.1: isopropylmagnesium chloride / tetrahydrofuran / Inert atmosphere
4.2: -5 - 5 °C / Inert atmosphere
4.3: -5 - 5 °C / Inert atmosphere
5.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 20 - 25 °C
6.1: hydrogen bromide; acetic acid / 20 - 30 °C
6.2: 20 - 25 °C
With
bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); 5%-palladium/activated carbon; hydrogen bromide; hydrogen; isopropylmagnesium chloride; sodium methylate; acetic acid;
In
tetrahydrofuran; methanol; n-heptane; toluene; acetonitrile;
1.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 20 - 25 °C
2.1: hydrogen bromide; acetic acid / 20 - 30 °C
2.2: 20 - 25 °C
With
lithium aluminium tetrahydride; hydrogen bromide; acetic acid;
In
tetrahydrofuran; toluene;
