Siponimod

Base Information

Chemical Name:Siponimod
CAS No.:1418144-65-6
Molecular Formula:C18H24F3NO2
Molecular Weight:343.389
Hs Code.:

Synonyms:Ethanimidic acid,N-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-, ethyl ester;N-[[4-Cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]ethanimidic acid ethyl ester

Suppliers and Price of Siponimod

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 24 raw suppliers

Chemical Property of Siponimod

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Siponimod

There total 15 articles about Siponimod which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261952-20-9
1-bromo-4-methyl-2-(trifluoromethyl)benzene

: 1418144-65-6
N-(4-cyclohexyl-3-trifluoromethylbenzyloxy)acetimidic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium methylate / methanol / 100 °C

2.1: hydrogen; 5%-palladium/activated carbon / methanol / 16 h / 60 °C / 3750.38 Torr

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / n-heptane; acetonitrile / 80 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / Inert atmosphere

4.2: -5 - 5 °C / Inert atmosphere

4.3: -5 - 5 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 20 - 25 °C

6.1: hydrogen bromide; acetic acid / 20 - 30 °C

6.2: 20 - 25 °C

7.1: dmap; potassium carbonate / dichloromethane; acetone / 50 - 52 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); 5%-palladium/activated carbon; hydrogen bromide; hydrogen; isopropylmagnesium chloride; sodium methylate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; n-heptane; dichloromethane; acetone; toluene; acetonitrile; 1.1: |Suzuki Coupling;

Reference yield:

: 10576-12-2
ethyl acetohydroximate

: 800381-60-6
4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene

: 1418144-65-6
N-(4-cyclohexyl-3-trifluoromethylbenzyloxy)acetimidic acid ethyl ester

Guidance literature:: With dmap; potassium carbonate; In dichloromethane; acetone; at 50 - 52 ℃; Reagent/catalyst; Temperature; Solvent; Concentration; Time;

Reference yield:

: 261763-23-9
4-(bromomethyl)-1-chloro-2-(trifluoromethyl)benzene

: 1418144-65-6
N-(4-cyclohexyl-3-trifluoromethylbenzyloxy)acetimidic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 5 h / 20 °C

2.1: zinc(II) chloride; 1-methyl-pyrrolidin-2-one / diethyl ether / 0.58 h / 20 - 80 °C / Inert atmosphere

2.2: 1 h / 140 °C / Inert atmosphere

With 1-methyl-pyrrolidin-2-one; potassium tert-butylate; zinc(II) chloride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ml300396r