Technology Process of Propanal,
2-[bis(phenylmethyl)amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-,
(2S)-
There total 1 articles about Propanal,
2-[bis(phenylmethyl)amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-,
(2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
2.1: n-BuLi / hexane; tetrahydrofuran / 2 h / -20 °C
2.2: 80 percent / BF3*Et2O / hexane; tetrahydrofuran / -78 - 20 °C
3.1: 82 percent / TBAF / tetrahydrofuran / 4 h / -20 °C
4.1: CSA / acetone / 14 h / 50 °C
4.2: 80 percent / acetic acid / tetrahydrofuran; H2O
5.1: 99 percent / quinoline; hydrogen / Lindlar catalyst / ethanol; diethyl ether; hexane / 0.33 h / 20 °C / 760 Torr
6.1: 30.9 mg / pyridine; methyltrioxorhenium; H2O2 / CH2Cl2 / 4 h / 20 °C
With
pyridine; quinoline; n-butyllithium; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; methyltrioxorhenium(VII);
Lindlar's catalyst;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; acetone;
DOI:10.1021/ol062804a
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
2.1: n-BuLi / hexane; tetrahydrofuran / 2 h / -20 °C
2.2: 80 percent / BF3*Et2O / hexane; tetrahydrofuran / -78 - 20 °C
3.1: 82 percent / TBAF / tetrahydrofuran / 4 h / -20 °C
4.1: CSA / acetone / 14 h / 50 °C
4.2: 80 percent / acetic acid / tetrahydrofuran; H2O
5.1: 99 percent / quinoline; hydrogen / Lindlar catalyst / ethanol; diethyl ether; hexane / 0.33 h / 20 °C / 760 Torr
6.1: 30.9 mg / pyridine; methyltrioxorhenium; H2O2 / CH2Cl2 / 4 h / 20 °C
7.1: B(OMe)3 / dimethylformamide / 0.33 h / 20 °C
7.2: 10.8 mg / NaN3 / dimethylformamide / 15 h / 50 °C
With
pyridine; quinoline; n-butyllithium; Trimethyl borate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; methyltrioxorhenium(VII);
Lindlar's catalyst;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol062804a
