(S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine

Base Information

Chemical Name:(S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine
CAS No.:929006-76-8
Molecular Formula:C₃₄H₃₉NO₂Si
Molecular Weight:521.775
Hs Code.:

Synonyms:(S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine

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Technology Process of (S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine

There total 4 articles about (S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929006-90-6
(2R,3S)-4-(tert-butyldiphenylsilyloxy)-1-chloro-3-(dibenzylamino)butan-2-ol

: 929006-76-8
(S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;
DOI:10.1021/ol062804a

Reference yield:

: 800391-48-4
3-(tert-butyl-diphenyl-silanyloxy)-2-dibenzylamino-propionaldehyde

: 75-11-6
diiodomethane

: 929006-76-8
(S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine

: (2S)-2-{1'-(S)-(dibenzylamino)-2'-[(tert-butyldiphenylsilanyl)oxy]ethyl}oxirane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/ol062804a

Reference yield:

: 3-(tert-butyl-diphenyl-silanyloxy)-2-dibenzylamino-propionic acid methyl ester

: 929006-76-8
(S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi / hexane; tetrahydrofuran / 1.5 h / -78 °C

2: LAH / tetrahydrofuran / 20 h / -91 °C

3: 181 mg / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 20 °C

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/ol062804a