2,6-DiMethyltyrosine HCl

Base Information

• Chemical Name: 2,6-DiMethyltyrosine HCl
• CAS No.: 80110-73-2
• Molecular Formula: C₁₁H₁₅NO₃*ClH
• Molecular Weight: 245.706
• Mol file: 80110-73-2.mol

Synonyms:2,6-Dimethyl-L-tyrosine hydrochloride;DL-Tyrosine,2,6-dimethyl-,hydrochloride;

Chemical Property of 2,6-DiMethyltyrosine HCl

Chemical Property:

• PSA: 83.55000
• LogP: 2.46570

Purity/Quality:

99% ^*data from raw suppliers

2,6-DiMethyltyrosineHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DiMethyltyrosine HCl

There total 14 articles about 2,6-DiMethyltyrosine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-N-Boc-2,6-dimethyltyrosine (99953-00-1,111633-04-6) → 2,6-dimethyl-(S)-tyrosine hydrochloride (80110-73-2,126312-63-8)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/acs.joc.8b03283

Reference yield: 95.0%

2,6-dimethyl-L-tyrosine ethyl ester dibenzoyl-L-tartaric acid → 2,6-dimethyl-(S)-tyrosine hydrochloride (80110-73-2,126312-63-8)

Guidance literature:

2,6-dimethyl-L-tyrosine ethyl ester dibenzoyl-L-tartaric acid; With water; sodium hydroxide; In dichloromethane;

With hydrogenchloride; water; for 5h; Reflux;

Reference yield:

c(DMT-Val) → L-valine hydrochloride (17498-50-9,25616-14-2,31320-20-4) + 2,6-dimethyl-(S)-tyrosine hydrochloride (80110-73-2,126312-63-8)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 24h;

DOI:10.1002/jhet.2489

upstream raw materials:

(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionic acid methyl ester; hydrochloride

2,6-dimethyl-4-hydroxybenzaldehyde

4-(benzyloxy)-2,6-dimethylbenzaldehyde

di-tert-butyl dicarbonate

Refernces

• 1、 Pacifico, Salvatore,Albanese, Valentina,Illuminati, Davide,Marzola, Erika,Fabbri, Martina,Ferrari, Federica,Holanda, Victor A.D.,Sturaro, Chiara,Malfacini, Davide,Ruzza, Chiara,Trapella, Claudio,Preti, Delia,Lo Cascio, Ettore,Arcovito, Alessandro,Della Longa, Stefano,Marangoni, Martina,Fattori, Davide,Nassini, Romina,Calò, Girolamo,Guerrini, Remo. "Novel Mixed NOP/Opioid Receptor Peptide Agonists". supporting information. p. 6656 - 6669. Retrieved 2021/06/25.
• 2、 Chingle, Ramesh,Mulumba, Mukandila,Chung, Nga N.,Nguyen, Thi M.-D.,Ong, Huy,Ballet, Steven,Schiller, Peter W.,Lubell, William D.. "Solid-Phase Azopeptide Diels-Alder Chemistry for Aza-pipecolyl Residue Synthesis to Study Peptide Conformation". . p. 6006 - 6016. Retrieved 2019/05/24.