2,6-Dimethyl-4-hydroxybenzaldehyde

Base Information

• Chemical Name: 2,6-Dimethyl-4-hydroxybenzaldehyde
• CAS No.: 70547-87-4
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Hs Code.: 2912499000
• Mol file: 70547-87-4.mol

Synonyms:4-Hydroxy-2,6-dimethylbenzaldehyde;

Chemical Property of 2,6-Dimethyl-4-hydroxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.0018mmHg at 25°C
• Melting Point: 190-196 °C
• Refractive Index: 1.589
• Boiling Point: 283.8 °C at 760 mmHg
• PKA: 8.02±0.23(Predicted)
• Flash Point: 119 °C
• PSA: 37.30000
• Density: 1.136 g/cm³
• LogP: 1.82150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dimethyl-4-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dimethyl-4-hydroxybenzaldehyde

There total 18 articles about 2,6-Dimethyl-4-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(tert-butyldimethylsilanyloxy)-2,6-dimethylbenzaldehyde (378185-89-8) → 2,6-dimethyl-4-hydroxybenzaldehyde (70547-87-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1080/00304940709356013

Reference yield: 65.0%

Dichloromethyl methyl ether (4885-02-3) + 3,5-Dimethylphenol (108-68-9,50356-23-5) → 2,6-dimethyl-4-hydroxybenzaldehyde (70547-87-4) + 2-hydroxy-4,6-dimethylbenzaldehyde (1666-02-0)

Guidance literature:

3,5-Dimethylphenol; With titanium tetrachloride; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

Dichloromethyl methyl ether; In dichloromethane; at 0 ℃; for 0.75h; Overall yield = 78 %; Inert atmosphere;

DOI:10.3390/molecules20045409

Reference yield: 10.0%

chloroform (67-66-3,8013-54-5) + 3,5-Dimethylphenol (108-68-9,50356-23-5) → 2,6-dimethyl-4-hydroxybenzaldehyde (70547-87-4)

Guidance literature:

With potassium hydroxide; In water; at 60 ℃; for 18h;

DOI:10.1039/b100757m

upstream raw materials:

4-iodo-3,5-dimethylphenol

hydrogen cyanide

3,5-Dimethylphenol

dicyanozinc

Downstream raw materials:

4-hydroxy-2,6-dimethyl-benzaldehyde-oxime

4-methoxy-2,6-dimethylbenzylaldehyde

2-<(4-hydroxy-2,6-dimethylphenyl)methylene>hydrazinecarboximidamide

2,6-dimethyl-4-hydroxybenzyl alcohol

Refernces

• 1、 Yamada,Toyota,Takakura,Ishimaru,Sugawara. "Preparation of BODIPY probes for multicolor fluorescence imaging studies of membrane dynamics". . p. 667 - 669. Retrieved 2001.
• 2、 Warashina, Takuya,Matsuura, Daisuke,Kimura, Yoshikazu. "Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers". . p. 587 - 593. Retrieved 2019/07/22.
• 3、 Ramos-Tomillero, Iván,Paradís-Bas, Marta,De Pinho Ribeiro Moreira, Ibério,Bofill, Josep María,Nicolás, Ernesto,Albericio, Fernando. "Formylation of electron-rich aromatic rings mediated by dichloromethyl methyl ether and TiCl4: Scope and limitations". supporting information. p. 5409 - 5422. Retrieved 2015/05/13.