10-Oxa-2,5,8-triazadodecanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-2-fluorophenyl]methyl]-3-(2-methoxy -2-oxoethyl)-11,11-dimethyl-4,9-dioxo-, phenylmethyl ester, (3S)-

Base Information

Chemical Name:10-Oxa-2,5,8-triazadodecanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-2-fluorophenyl]methyl]-3-(2-methoxy -2-oxoethyl)-11,11-dimethyl-4,9-dioxo-, phenylmethyl ester, (3S)-
CAS No.:801239-65-6
Molecular Formula:C32H42FN3O9
Molecular Weight:631.699
Hs Code.:

10-Oxa-2,5,8-triazadodecanoic acid,
5-[[5-[(1,1-dimethylethoxy)carbonyl]-2-fluorophenyl]methyl]-3-(2-methoxy
-2-oxoethyl)-11,11-dimethyl-4,9-dioxo-, phenylmethyl ester, (3S)-

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Chemical Property of 10-Oxa-2,5,8-triazadodecanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-2-fluorophenyl]methyl]-3-(2-methoxy -2-oxoethyl)-11,11-dimethyl-4,9-dioxo-, phenylmethyl ester, (3S)-

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Technology Process of 10-Oxa-2,5,8-triazadodecanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-2-fluorophenyl]methyl]-3-(2-methoxy -2-oxoethyl)-11,11-dimethyl-4,9-dioxo-, phenylmethyl ester, (3S)-

There total 3 articles about 10-Oxa-2,5,8-triazadodecanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-2-fluorophenyl]methyl]-3-(2-methoxy -2-oxoethyl)-11,11-dimethyl-4,9-dioxo-, phenylmethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 3160-47-2
N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester

: 801239-62-3
3-[(2-tert-butoxycarbonylamino-ethylamino)-methyl]-4-fluoro-benzoic acid tert-butyl ester

: 801239-65-6
3-{[(2-benzyloxycarbonylamino-3-methoxycarbonyl-propionyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-4-fluoro-benzoic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 24h;
DOI:10.1021/jm049666k

Reference yield:

: 57260-73-8
N-BOC-1,2-diaminoethane

: 801239-65-6
3-{[(2-benzyloxycarbonylamino-3-methoxycarbonyl-propionyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-4-fluoro-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / dimethylformamide / 3 h / 20 °C

2: 69 percent / EDC; HOBT / dimethylformamide / 24 h

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049666k

Reference yield:

: 193473-82-4
tert-butyl-4-fluoro-3(alpha-bromomethyl)benzoate

: 801239-65-6
3-{[(2-benzyloxycarbonylamino-3-methoxycarbonyl-propionyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-4-fluoro-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / dimethylformamide / 3 h / 20 °C

2: 69 percent / EDC; HOBT / dimethylformamide / 24 h

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049666k