6,9,12-Trioxa-2,16-diazaheptadecanedioic acid, 2-[[2-bromo-5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]-, 17-(1,1-dimethylethyl) 1-(phenylmethyl) ester

Base Information

Chemical Name:6,9,12-Trioxa-2,16-diazaheptadecanedioic acid, 2-[[2-bromo-5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]-, 17-(1,1-dimethylethyl) 1-(phenylmethyl) ester
CAS No.:801239-82-7
Molecular Formula:C46H61BrN2O8Si
Molecular Weight:877.988
Hs Code.:

6,9,12-Trioxa-2,16-diazaheptadecanedioic acid,
2-[[2-bromo-5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]-,
17-(1,1-dimethylethyl) 1-(phenylmethyl) ester

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Chemical Property of 6,9,12-Trioxa-2,16-diazaheptadecanedioic acid, 2-[[2-bromo-5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]-, 17-(1,1-dimethylethyl) 1-(phenylmethyl) ester

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Technology Process of 6,9,12-Trioxa-2,16-diazaheptadecanedioic acid, 2-[[2-bromo-5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]-, 17-(1,1-dimethylethyl) 1-(phenylmethyl) ester

There total 2 articles about 6,9,12-Trioxa-2,16-diazaheptadecanedioic acid, 2-[[2-bromo-5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]methyl]-, 17-(1,1-dimethylethyl) 1-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 801239-82-7
(3-{2-[2-(3-{benzyloxycarbonyl-[2-bromo-5-(tert-butyl-diphenyl-silanyloxy)-benzyl]-amino}-propoxy)-ethoxy]-ethoxy}-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: BBr₃ / CH₂Cl₂ / 2 h / -20 - 0 °C

2.1: 5.1 g / DMAP; iPr₂EtN / CH₂Cl₂ / 16 h / 0 °C

3.1: dimethylformamide / 20 °C

3.2: 1.8 g / aq. NaHCO₃ / diethyl ether / 0.25 h / 0 °C

With dmap; boron tribromide; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049666k

Reference yield:

: 54900-61-7
4-bromo-3-(bromomethyl)phenol

: 801239-82-7
(3-{2-[2-(3-{benzyloxycarbonyl-[2-bromo-5-(tert-butyl-diphenyl-silanyloxy)-benzyl]-amino}-propoxy)-ethoxy]-ethoxy}-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 5.1 g / DMAP; iPr₂EtN / CH₂Cl₂ / 16 h / 0 °C

2.1: dimethylformamide / 20 °C

2.2: 1.8 g / aq. NaHCO₃ / diethyl ether / 0.25 h / 0 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049666k

Reference yield: 88.0%

: 617-52-7
Dimethyl itakonate

: 801239-82-7
(3-{2-[2-(3-{benzyloxycarbonyl-[2-bromo-5-(tert-butyl-diphenyl-silanyloxy)-benzyl]-amino}-propoxy)-ethoxy]-ethoxy}-propyl)-carbamic acid tert-butyl ester

: 2-[1-[2-{[Benzyloxycarbonyl-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-amino]-methyl}-4-(tert-butyl-diphenyl-silanyloxy)-phenyl]-meth-(E)-ylidene]-succinic acid dimethyl ester

Guidance literature:: With palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In various solvent(s); at 90 ℃; for 3h;
DOI:10.1021/jm049666k