Cycloheptanecarboxaldehyde, 2-(phenylmethoxy)-1-[3-(phenylmethoxy)propyl]-, (1R,2R)-

Base Information

Chemical Name:Cycloheptanecarboxaldehyde, 2-(phenylmethoxy)-1-[3-(phenylmethoxy)propyl]-, (1R,2R)-
CAS No.:802903-31-7
Molecular Formula:C25H32O3
Molecular Weight:380.527
Hs Code.:

Synonyms:

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Chemical Property of Cycloheptanecarboxaldehyde, 2-(phenylmethoxy)-1-[3-(phenylmethoxy)propyl]-, (1R,2R)-

Chemical Property:

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Technology Process of Cycloheptanecarboxaldehyde, 2-(phenylmethoxy)-1-[3-(phenylmethoxy)propyl]-, (1R,2R)-

There total 5 articles about Cycloheptanecarboxaldehyde, 2-(phenylmethoxy)-1-[3-(phenylmethoxy)propyl]-, (1R,2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,2R)-2-Benzyloxy-1-(3-benzyloxy-propyl)-1-((E)-styryl)-cycloheptane

: 802903-31-7
(1R,2R)-2-Benzyloxy-1-(3-benzyloxy-propyl)-cycloheptanecarbaldehyde

Guidance literature:: (1S,2R)-2-Benzyloxy-1-(3-benzyloxy-propyl)-1-((E)-styryl)-cycloheptane; With oxygen; In dichloromethane; at -78 ℃; for 0.0333333h;

With triphenylphosphine; In dichloromethane; at -78 - 20 ℃; for 2h;
DOI:10.1021/ja045849k

Reference yield:

: 55110-62-8
1-(2-phenylethynyl)cycloheptene

: 802903-31-7
(1R,2R)-2-Benzyloxy-1-(3-benzyloxy-propyl)-cycloheptanecarbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. KOH; tetrabutylammonium hydrogen sulfate; Shi's chiral ketone / oxone; Na₂EDTA / acetonitrile; various solvent(s); acetate buffer / 2 h / 0 °C

1.2: tetrahydrofuran / 20 °C

2.1: 9-BBN / tetrahydrofuran / 20 °C

2.2: aq. NaOH; aq. H₂O₂ / 3 h / 20 °C

3.1: pyridine; H₂ / Pd/BaSO₄ / 23 h / 760 Torr

4.1: NaH; tetrabutylammonium bromide / tetrahydrofuran / 0.5 h / 20 °C

4.2: tetrahydrofuran / 8 h / Heating

5.1: O₂ / CH₂Cl₂ / 0.03 h / -78 °C

5.2: PPh₃ / CH₂Cl₂ / 2 h / -78 - 20 °C

With pyridine; potassium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; Shi's ketone; tetrabutylammomium bromide; hydrogen; oxygen; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; Oxone; Pd-BaSO₄; edetate disodium; In tetrahydrofuran; dichloromethane; acetate buffer; acetonitrile;
DOI:10.1021/ja045849k

Reference yield:

: 802903-27-1
(1R,2S)-2-Allyl-2-phenylethynyl-cycloheptanol

: 802903-31-7
(1R,2R)-2-Benzyloxy-1-(3-benzyloxy-propyl)-cycloheptanecarbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-BBN / tetrahydrofuran / 20 °C

1.2: aq. NaOH; aq. H₂O₂ / 3 h / 20 °C

2.1: pyridine; H₂ / Pd/BaSO₄ / 23 h / 760 Torr

3.1: NaH; tetrabutylammonium bromide / tetrahydrofuran / 0.5 h / 20 °C

3.2: tetrahydrofuran / 8 h / Heating

4.1: O₂ / CH₂Cl₂ / 0.03 h / -78 °C

4.2: PPh₃ / CH₂Cl₂ / 2 h / -78 - 20 °C

With pyridine; 9-borabicyclo[3.3.1]nonane dimer; tetrabutylammomium bromide; hydrogen; oxygen; sodium hydride; Pd-BaSO₄; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja045849k