5-(1H-indol-2-yl)-3-Methoxy-1H-pyrrole-2-carbaldehyde, 3-Methoxy-5-indol-2-yl-1H-pyrrole-2-carbaldehyde, 5-indolyl-3-Methoxypyrrole-2-carboxaldehyde

Base Information

• Chemical Name: 5-(1H-indol-2-yl)-3-Methoxy-1H-pyrrole-2-carbaldehyde, 3-Methoxy-5-indol-2-yl-1H-pyrrole-2-carbaldehyde, 5-indolyl-3-Methoxypyrrole-2-carboxaldehyde
• CAS No.: 803712-70-1
• Molecular Formula: C14H12N2O2
• Molecular Weight: 240.25700
• Hs Code.: 2933990090
• Mol file: 803712-70-1.mol

Synonyms:5-indolyl-3-methoxypyrrole-2-carboxaldehyde;3-methoxy-5-indol-2-yl-1H-pyrrole-2-carbaldehyde;

Chemical Property of 5-(1H-indol-2-yl)-3-Methoxy-1H-pyrrole-2-carbaldehyde, 3-Methoxy-5-indol-2-yl-1H-pyrrole-2-carbaldehyde, 5-indolyl-3-Methoxypyrrole-2-carboxaldehyde

Chemical Property:

• PSA: 57.88000
• LogP: 2.98410
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

5-(1H-Indol-2-yl)-3-methoxy-1H-pyrrole-2-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(1H-indol-2-yl)-3-Methoxy-1H-pyrrole-2-carbaldehyde, 3-Methoxy-5-indol-2-yl-1H-pyrrole-2-carbaldehyde, 5-indolyl-3-Methoxypyrrole-2-carboxaldehyde

There total 14 articles about 5-(1H-indol-2-yl)-3-Methoxy-1H-pyrrole-2-carbaldehyde, 3-Methoxy-5-indol-2-yl-1H-pyrrole-2-carbaldehyde, 5-indolyl-3-Methoxypyrrole-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl 2-(5-formyl-4-methoxy-1H-pyrrol-2-yl)-1H-indole-1-carboxylate (1033391-26-2) → tert-butyl 2-(5-formyl-4-methoxy-1H-pyrrol-2-yl)-1H-indole-1-carboxylate (803712-70-1)

Guidance literature:

With water; at 170 ℃; for 0.583333h; Microwave irradiation;

DOI:10.1002/chem.201101547

Reference yield: 78.0%

N-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)-methyl)-N-ethylethanamine (803712-71-2) + N-Boc-indole-2-boronic acid (213318-44-6) → tert-butyl 2-(5-formyl-4-methoxy-1H-pyrrol-2-yl)-1H-indole-1-carboxylate (803712-70-1)

Guidance literature:

N-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)-methyl)-N-ethylethanamine; N-Boc-indole-2-boronic acid; With sodium carbonate; triphenylphosphine; palladium diacetate; In 1,4-dioxane; water; toluene; at 100 ℃; for 3.5h;

With sodium methylate; In 1,4-dioxane; water; toluene; at 100 ℃; for 0.416667h; Further stages.;

DOI:10.1039/b801677a

Reference yield: 75.0%

(E)-N-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)methyl)-N-ethylethanamine + N-Boc-indole-2-boronic acid (213318-44-6) → tert-butyl 2-(5-formyl-4-methoxy-1H-pyrrol-2-yl)-1H-indole-1-carboxylate (803712-70-1)

Guidance literature:

(E)-N-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)methyl)-N-ethylethanamine; N-Boc-indole-2-boronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; toluene; at 100 ℃; for 3h;

With sodium methylate; In 1,4-dioxane; water; toluene; at 100 ℃; for 0.416667h;

upstream raw materials:

N-Boc-indole-2-boronic acid

N-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)-methyl)-N-ethylethanamine

N-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)methyl)-N-ethylethanamine

4-methoxy-3-pyrrolin-2-one

Downstream raw materials:

obatoclax

obatoclax

Refernces

• 1、 Su, Jung-Chen,Wu, Szu-Hsien,Shiau, Chung-Wai,Chang, Chuan-Hsun. "Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1". . p. 1248 - 1255. Retrieved 2018/10/31.
• 2、 Papireddy, Kancharla,Smilkstein, Martin,Kelly, Jane Xu,Shweta,Salem, Shaimaa M.,Alhamadsheh, Mamoun,Haynes, Stuart W.,Challis, Gregory L.,Reynolds, Kevin A.. "Antimalarial activity of natural and synthetic prodiginines". . p. 5296 - 5306. Retrieved 2011/10/02.