4-Bromo-2,6-di-tert-butylanisole

Base Information

• Chemical Name: 4-Bromo-2,6-di-tert-butylanisole
• CAS No.: 1516-96-7
• Molecular Formula: C15H23BrO
• Molecular Weight: 299.251
• Hs Code.: 2909309090
• Mol file: 1516-96-7.mol

Synonyms:4-Bromo-2,6-di-tert-butylphenyl methyl ether;5-Bromo-1,3-di-tert-butyl-2-methoxybenzene;benzene, 5-bromo-1,3-bis(1,1-dimethylethyl)-2-methoxy-;

Chemical Property of 4-Bromo-2,6-di-tert-butylanisole

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 49-50 ºC
• Refractive Index: 1.5
• Boiling Point: 304 ºC
• Flash Point: 128 ºC
• PSA: 9.23000
• Density: 1.137
• LogP: 5.05270
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-1,3-di-tert-butyl-2-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2,6-di-tert-butylanisole

There total 7 articles about 4-Bromo-2,6-di-tert-butylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2,6-di-tert-butylphenol (1139-52-2) + dimethyl sulfate (77-78-1) → 4-bromo-2,6-di-tert-butylanisole (1516-96-7)

Guidance literature:

4-bromo-2,6-di-tert-butylphenol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

dimethyl sulfate; In tetrahydrofuran; for 17h; Heating;

DOI:10.1021/ja066800c

Reference yield: 100.0%

4-bromo-2,6-di-tert-butylphenol (1139-52-2) + methyl iodide (74-88-4) → 4-bromo-2,6-di-tert-butylanisole (1516-96-7)

Guidance literature:

4-bromo-2,6-di-tert-butylphenol; With sodium hydride; In dimethyl sulfoxide; oil; at 0 ℃; Inert atmosphere;

methyl iodide; In dimethyl sulfoxide; oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol802431v

Reference yield: 98.7%

2,6-di-tert-butyl-anisole (1516-95-6) → 4-bromo-2,6-di-tert-butylanisole (1516-96-7)

Guidance literature:

With 2,4,6-trimethylaniline; In dichloromethane; at 25 ℃; for 3.5h;

DOI:10.1002/ejoc.202000336

upstream raw materials:

4-bromo-2,6-di-tert-butylphenol

methyl iodide

dimethyl sulfate

2,6-di-tert-butyl-anisole

Downstream raw materials:

1-(3,5-di-tert-butyl-4-methoxy-phenyl)-1H-imidazole

4-methoxy-3,5-di-tert-butylphenylboronic acid pinacol ester

4-(3,5-di-tert-butyl-4-methoxyphenyl)pyridine

C₂₆H₃₅NO

Refernces

• 1、 Kobayashi, Ryo,Ishida, Shintaro,Iwamoto, Takeaki. "An Isolable Silicon Analogue of a Ketone that Contains an Unperturbed Si=O Double Bond". . p. 9425 - 9428. Retrieved 2019.
• 2、 Matsude, Akihiro,Hirano, Koji,Miura, Masahiro. "Highly Stereoselective Synthesis of 1,2-Disubstituted Indanes by Pd-Catalyzed Heck/Suzuki Sequence of Diarylmethyl Carbonates". . p. 3190 - 3194. Retrieved 2020.
• 3、 -. "Preparation method of 2, 6-di-tert-butyl-4-bromoanisole". Paragraph 0054-0063; 0082-0099. . Retrieved 2021/11/06.