Thieno[2,3-b]pyridine-5-carboxamide, 2-[[[2-(2-benzofuranyl)-2-hydroxyethyl]methylamino]methyl]-N-[(4-chloro phenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7-dihydro-4- oxo-

Base Information

Chemical Name:Thieno[2,3-b]pyridine-5-carboxamide, 2-[[[2-(2-benzofuranyl)-2-hydroxyethyl]methylamino]methyl]-N-[(4-chloro phenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7-dihydro-4- oxo-
CAS No.:804511-26-0
Molecular Formula:C33H34ClN3O6S
Molecular Weight:636.168
Hs Code.:

Thieno[2,3-b]pyridine-5-carboxamide,
2-[[[2-(2-benzofuranyl)-2-hydroxyethyl]methylamino]methyl]-N-[(4-chloro
phenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7-dihydro-4-
oxo-

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Chemical Property of Thieno[2,3-b]pyridine-5-carboxamide, 2-[[[2-(2-benzofuranyl)-2-hydroxyethyl]methylamino]methyl]-N-[(4-chloro phenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7-dihydro-4- oxo-

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Technology Process of Thieno[2,3-b]pyridine-5-carboxamide, 2-[[[2-(2-benzofuranyl)-2-hydroxyethyl]methylamino]methyl]-N-[(4-chloro phenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7-dihydro-4- oxo-

There total 5 articles about Thieno[2,3-b]pyridine-5-carboxamide, 2-[[[2-(2-benzofuranyl)-2-hydroxyethyl]methylamino]methyl]-N-[(4-chloro phenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7-dihydro-4- oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 556025-48-0
1-(benzofuran-2-yl)-2-(methylamino)ethanol

: 672326-05-5
2-(chloromethyl)-N-((4-chlorophenyl)methyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4,7-dihydro-4-oxothieno[2,3-b]-pyridine-5-carboxamide

: 804511-26-0
2-(((2-(1-benzofuran-2-yl)-2-hydroxyethyl)(methyl)amino)methyl)-N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamide

Guidance literature:: With cesium carbonate; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 17h; 3 ? molecular sieves;

Reference yield:

: 292144-08-2,863102-00-5
N-(4-chlorobenzyl)-4-hydroxy-2-(hydroxymethyl)thieno[2,3-b]pyridine-5-carboxamide

: 804511-26-0
2-(((2-(1-benzofuran-2-yl)-2-hydroxyethyl)(methyl)amino)methyl)-N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: cesium carbonate / DMF (N,N-dimethyl-formamide) / 17 h / 100 °C

2: 2,4,6-trimethyl-pyridine; dmap; methanesulfonyl chloride / DMF (N,N-dimethyl-formamide) / 4 h / 20 °C

3: cesium carbonate / DMF (N,N-dimethyl-formamide) / 17 h / 60 °C / 3 ? molecular sieves

With 2,4,6-trimethyl-pyridine; dmap; cesium carbonate; methanesulfonyl chloride; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 36236-76-7
4-(bromomethyl)-2,2-dimethyl-1,3-dioxolane

: 804511-26-0
2-(((2-(1-benzofuran-2-yl)-2-hydroxyethyl)(methyl)amino)methyl)-N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: cesium carbonate / DMF (N,N-dimethyl-formamide) / 17 h / 100 °C

2: 2,4,6-trimethyl-pyridine; dmap; methanesulfonyl chloride / DMF (N,N-dimethyl-formamide) / 4 h / 20 °C

3: cesium carbonate / DMF (N,N-dimethyl-formamide) / 17 h / 60 °C / 3 ? molecular sieves

With 2,4,6-trimethyl-pyridine; dmap; cesium carbonate; methanesulfonyl chloride; In DMF (N,N-dimethyl-formamide);