36236-76-7

Basic information

• Product Name: 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane
• Synonyms: 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane;4-(BroMoMethyl)-2,2-diMethyl-1,3-dioxolane;DL-Isopropylideneglycerol-1-bromohydrin
• CAS NO: 36236-76-7
• Molecular Formula: C₆H₁₁BrO₂
• Molecular Weight: 195.05434
• EINECS: 604-604-1
• Mol File: 36236-76-7.mol

Chemical Properties

• Boiling Point: 75℃ (10 Torr)
• Flash Point: 74.8°C
• Appearance: /
• Density: 1.359g/cm³
• Vapor Pressure: 0.688mmHg at 25°C
• Refractive Index: 1.4597 (589.3 nm 20℃)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane(36236-76-7)
• EPA Substance Registry System: 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane(36236-76-7)

Safety Data

• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 36236-76-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane is used as a reagent for various organic synthesis processes. Its bromomethyl moiety enables a range of reactions, such as cross-linking, joining, or extending molecular chains, making it a versatile compound in the field of organic chemistry.
Used in Chemical Research:
In the field of chemical research, 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane is used as a model compound to study the properties and reactions of acetals and other related compounds. This helps in understanding the behavior of these compounds under different conditions and their potential applications in various industries.
Used in Pharmaceutical Industry:
4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane is used as an intermediate in the synthesis of pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block for the development of new drugs and therapeutic agents.
Used in Material Science:
In material science, 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane is used as a precursor for the synthesis of advanced materials, such as polymers and composites, with specific properties tailored for various applications, including electronics, coatings, and adhesives.

InChI:InChI=1/C6H11BrO2/c1-6(2)8-4-5(3-7)9-6/h5H,3-4H2,1-2H3

Upstream product

• 776-74-9 Bromodiphenylmethane 
• 67-64-1 acetone 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 4704-77-2 1-bromo-2,3-propanediol 
• 584-08-7 potassium carbonate 
• 34832-91-2 1,2-O-isopropylideneglyceryl N,N,N'N,-tetraethylphosphorodiamidite 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 4704-77-2 1-bromo-2,3-propanediol 
• 505-23-7 1,3 dithiane 
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• 142103-84-2 5-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-2-nitro-benzaldehyde 
• 102685-89-2 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-benzamide 
• 64445-12-1 2-(4-Isobutyl-phenyl)-propionic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 
• 64749-86-6 3-benziloyloxy-1-(2,2-dimethyl-1,3-dioxolan-4ylmethyl)piperidine 
• 91540-06-6 4-benziloyloxy-1-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)piperidine 
• 64445-11-0 Hydroxy-phenyl-acetic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 
• 91614-23-2 Diphenyl-acetic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 
• 91522-56-4 Cyclohexyl-hydroxy-phenyl-acetic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 
• 672326-03-3 N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-2-(hydroxymethyl)-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide 
• 1082746-58-4 3,23-dihydroxy-20⁽²⁹⁾-lupen-28-oic acid 2,2-dimethyl-1,3-dioxolane-4-yl methyl ester 
• 1038914-88-3 N-[2-(N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-1H-indol-3-yl)-2-oxoethyl]-2-(3,4,5-trimethoxyphenyl)acetamide 

Relevant articles and documents

NOVEL COMPOUNDS, FUNCTIONALISED DIOXABOROLANE OR DIOXABORINANE DERIVATIVES, METHOD FOR PREPARING SAME AND USES THEREOF

The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R1 is covalently bonded to the boron atom by a carbon atom; one of R2, R3, R′3 or R4 is a radical of formula —X; or one of R1, R2, R3, R′3 or R4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.

BIPHENYL CARBOXYLIC AMIDE P38 KINASE INHIBITORS

Compounds of formula (I) or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.

Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions

Quaternary amine-containing ether lipid analogs of the formula are disclosed. R1 represents a hydrophobic group and R2 represents the backbone of the molecule, with the quaternary amine being linked directly to the backbone. Pharmaceutical compositions including these compounds and methods of combating tumors with these compounds are disclosed. Also disclosed is a method of combating viral infections with both these compounds and ET-18-OMe and its analogs.

Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols and potent inhibitors of protein kinase C

Alyklglycerols such as rac-1-O-octadecyl-2-O-methylglycerophosphochocholine (Et-18-OMe) have shown an inhibitory effect on the metastasis and growth of various cancer cell lines. Alkyl phospholipids have been shown to accumulate at the surface in several cell lines, the selectivity of which is still not clearly understood. A consequence of this action may lead to the inhibition of cell membrane related protein kinase C (PKC). The goal of this research was to develop ether lipid inhibitors of PKC to augment antineoplastic activity. This led to the synthesis and in vitro testing of a series of novel quaternary ammonium derivatives of alkylglycerols. The biological testing of these analogues on PKC stimulated with rac-1-O-oleoyl-2-O-acetylglycerol showed several analogues with inhibition comparable to that of Et-18-OMe.

Oxime ethers, the preparation thereof, compositions containing them and use thereof

The invention relates to oxime ethers of the formula I STR1 wherein n is 1 or 2, each of R1 and R2 is hydrogen or C1 -C4 alkyl each of R3 and R4 is hydrogen, halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, C1 -C4 alkoxy, C1 -C4 haloalkoxy, C1 -C4 alkylthio, C1 -C4 haloalkylthio, C1 -C4 alkylsulfinyl, C1 -C4 alkylsulfonyl, C1 -C4 haloalkylsulfinyl, C1 -C4 haloalkylsulfonyl or nitro; each of R5 and R6 independently of the other is hydrogen, C1 -C4 alkyl, C1 -C4 haloalkyl, phenyl or phenyl which is substituted by halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, C1 -C4 alkoxy, C1 -C4 haloalkoxy, C1 -C4 alkylthio, C1 -C4 alkylsulfinyl, C1 -C4 alkylsulfonyl, carboxyl, carbamoyl, C 1 -C4 alkylcarbamoyl, nitro or cyano, or R5 and R6 together are also a 2- to 6-membered alkylene or alkenylene chain which may be substituted by C1 -C4 alkyl radicals; X is hydrogen, cyano, nitro, chlorine, C1 -C4 alkyl, C1 -C4 haloalkyl, C3 -C6 cycloalkyl, carboxyl, carbamoyl, C1 -C4 alkylcarbonyl, C1 -C4 alkoxycarbonyl or C1 -C4 alkylcarbamoyl. The oxime ethers of the formula I are able to act as antidotes or safeners to protect cultivated plants from the phytotoxic effects of herbicides. Such cultivated plants are preferably sorghum, cereals, maize and rice.

ANALYTICAL ENANTIOMER SEPARATION OF ALIPHATIC DIOLS AS BORONATES AND ACETALS BY COMPLEXATION GAS CHROMATOGRAPHY

Cyclic boronates and acetals of mono- and dialkylsubstituted 1,2-, 2,3- 1,3-and 1,4-diols have been quantitatively separated into enantiomers by complexation gas chromatography utilizing optically active metal chelates.An efficient, precise and sensitive method for determining enantiomeric purities for volatile glycols is thus available.