(6R,25R)-28-Deoxy-6,28-epoxy-25-ethylmilbemycin B

Base Information

Chemical Name:(6R,25R)-28-Deoxy-6,28-epoxy-25-ethylmilbemycin B
CAS No.:51596-13-5
Molecular Formula:C33H48O7
Molecular Weight:556.73
Hs Code.:
Nikkaji Number:J31.863I
Mol file:51596-13-5.mol

Synonyms:(6R,25R)-28-Deoxy-6,28-epoxy-25-ethylmilbemycin B;51596-13-5;Milbemycin B, 28-deoxy-6,28-epoxy-25-ethyl-, (6R,25R)-

Suppliers and Price of (6R,25R)-28-Deoxy-6,28-epoxy-25-ethylmilbemycin B

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (6R,25R)-28-Deoxy-6,28-epoxy-25-ethylmilbemycin B

Chemical Property:

PSA：83.45000
LogP:5.57840
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:556.34000387
Heavy Atom Count:40
Complexity:1070

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1C(CCC2(O1)CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5OC)C)C(=O)O3)O)C)C)C
Isomeric SMILES:CC[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5OC)C)C(=O)O3)O)C)\C)C

Technology Process of (6R,25R)-28-Deoxy-6,28-epoxy-25-ethylmilbemycin B

There total 2 articles about (6R,25R)-28-Deoxy-6,28-epoxy-25-ethylmilbemycin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 51596-11-3
milbemycin A4

: 74-88-4
methyl iodide

: 51596-13-5
5-O-methylmilbemycin A4

Guidance literature:: With silver(l) oxide; In acetonitrile; for 64h; Ambient temperature;
DOI:10.7164/antibiotics.47.233

Reference yield: 39.9%

: 51596-11-3
milbemycin A4

: 74-88-4
methyl iodide

: 51596-13-5
5-O-methylmilbemycin A4

: 5-O,7-O-dimethylmilbemycin A₄

Guidance literature:: With silver(l) oxide; In acetonitrile; at 20 ℃;
DOI:10.1271/bbb.66.1407

Reference yield:

: 51596-13-5
5-O-methylmilbemycin A4

: milbemycin β10

Guidance literature:: Multi-step reaction with 2 steps

1: 24.4 percent / CrO₃ / pyridine / 144 h / 20 °C

2: 49.6 percent / DIBAL-H / toluene; tetrahydrofuran / 1.83 h / 0 - 5 °C

With chromium(VI) oxide; diisobutylaluminium hydride; In tetrahydrofuran; pyridine; toluene;
DOI:10.1271/bbb.66.1407