N-{4-[(7-chloroquinolin-4-yl)amino]pentyl}-N-ethylacetamide

Base Information

• Chemical Name: N-{4-[(7-chloroquinolin-4-yl)amino]pentyl}-N-ethylacetamide
• CAS No.: 91828-61-4
• Molecular Formula: C₁₈H₂₄ClN₃O
• Molecular Weight: 333.861
• Mol file: 91828-61-4.mol

Synonyms:

Chemical Property of N-{4-[(7-chloroquinolin-4-yl)amino]pentyl}-N-ethylacetamide

Chemical Property:

• Vapor Pressure: 7.37E-11mmHg at 25°C
• Boiling Point: 518.6°C at 760 mmHg
• PKA: 6.36±0.27(Predicted)
• Flash Point: 267.4°C
• PSA: 0.00000
• Density: 1.171g/cm³
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{4-[(7-chloroquinolin-4-yl)amino]pentyl}-N-ethylacetamide

There total 3 articles about N-{4-[(7-chloroquinolin-4-yl)amino]pentyl}-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

desethylchloroquine (1476-52-4) + acetyl chloride (75-36-5) → rac-N-acetyldesethylchloroquine (91828-61-4)

Guidance literature:

With triethylamine; In dichloromethane; for 1h;

DOI:10.1002/jps.2600830722

Reference yield:

desethylchloroquine (1476-52-4) + acetyl chloride (75-36-5) → (R)-(-)-N-acetyldesethylchloroquine (91828-61-4) + (S)-(+)-N-acetyldesethylchloroquine (91828-61-4)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Yield given. Title compound not separated from byproducts;

DOI:10.1002/jps.2600830722

Reference yield:

desethylchloroquine (1476-52-4) + acetyl chloride (75-36-5) → (R)-(-)-N-acetyldesethylchloroquine (91828-61-4) + (S)-(+)-N-acetyldesethylchloroquine (91828-61-4)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Yield given. Title compound not separated from byproducts;

DOI:10.1002/jps.2600830722

upstream raw materials:

desethylchloroquine

acetyl chloride